- Article
- Source: Campus Sanofi
- Apr 1, 2024
One minute to ignite new thinking in COPD
What if you could identify higher-risk patients?
A deeper look at the inflammation behind exacerbations could ignite new thinking in COPD. Look for blood eosinophils, a biomarker of COPD with Type 2 Inflammation, which may help you identify those patients at increased risk of exacerbations.
Watch the video below to better understand exacerbations in COPD and better identify patients at risk.
Ignite new thinking in COPD - COPD, chronic obstructive pulmonary disease
In patients with COPD, exacerbations may :
- Increase the risk of another 1
- Accelerate lung function decline 2
- Increase morbidity and mortality risk 1,3-6
Different types of chronic inflammation have an important role in COPD 7-15
Type 2 inflammation and beyond type 2 inflammation
Identifying COPD patients with type 2 inflammation may help determine those at increased risk of exacerbations 16
Look for blood eosinophils, a biomarker of COPD with type 2 inflammation 17,18, a, b
EOS ≥ 300 cells/ μL à 32% increased risk of COPD exacerbations 16a,b
Understanding type 2 inflammation in COPD may shed light on why some patients continue to experience exacerbations
a Results from an observational analysis of 1553 patients with GOLD spirometry grade 2-4 COPD evaluating the relationship between blood eosinophil count and COPD exacerbation risk.
b Stratified analysis confirmed that increased exacerbation risk was driven by subjects with a history of frequent exacerbations, defined as ≥2 exacerbations per year.
References
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