- Article
- Source: Campus Sanofi
- Aug 5, 2025
Assessing fatigue in ITP patients
Tools for measurement
ITP Patient-Reported Outcomes Assessment Questionnaire (ITP-PAQ)5,6
ITP-PAQ is a validated tool that was designed to measure the HRQoL and treatment impact specifically for patients diagnosed with ITP.
The questionnaire typically evaluates various aspects of life affected by ITP, such as emotional well-being, and physical and social functioning. Additionally, the survey aids in assessing symptoms and their severity, including bruising and bleeding.
The ITP-PAQ facilitates a better overall understanding of how ITP affects individuals beyond clinical measures alone and their HRQoL.
ITP Life Quality Index (ILQI)1,6
The ILQI is a validated 10-item questionnaire that was developed to aid clinical discussions between patients and physicians about patients’ disease experiences, facilitating a patient-centric approach toward treatment decision-making. The ILQI typically involves surveys or questionnaires that patients complete, detailing their experiences, symptoms, and how these affect their quality of life.
Modified Fatigue Impact Scale (MFIS)2,7
The MFIS measures the impacts of fatigue on physical, cognitive, and psychosocial functioning.
This validated scale consists of a series of statements related to fatigue and its impact over a longer time, usually 4 weeks. The respondents rate their experiences over this period. The total scoring can then help healthcare providers understand the severity of fatigue and its effects on daily functioning.
In contrast to the MFIS, the daily fatigue impact scale (D-FIS) is a scoring tool to measure the short-term impact of fatigue in everyday life.
The Functional Assessment of Chronic Illness Therapy – Fatigue (FACIT-F)4,8
The FACIT-F is a validated scale that provides a 13-item tool to determine self-reported fatigue and its impact on daily activities and function.
The questionnaire includes questions regarding the intensity and frequency of fatigue, its effects on social and personal activities, and the overall energy level.
The Daytime Sleepiness Scale3
The daytime sleepiness scale is often represented by the validated Epworth Sleepiness Scale (ESS), a scale used to evaluate patients for excessive daytime sleepiness. The questionnaire measures how likely someone falls asleep in various situations.
References
1. Viana R, D’Alessio D, Grant L, et al. Psychometric evaluation of ITP Life Quality Index (ILQI) in a global survey of patients with immune thrombocytopenia. Adv Ther. 2021;38(12):5791-5808. 2. Larson RD. Psychometric properties of the modified fatigue impact scale. Int J MS Care. 2013;15(1):15-20. 3. Scharf MT. Reliability and efficacy of the Epworth Sleepiness Scale: is there still a place for it? Nat Sci Sleep. 2022;14:2151-2156. 4. Montan I, Löwe B, Cella D, Mehnert A, Hinz A. General population norms for the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale. Value Health. 2018;21(11):1313-1321. 5. Mathias SD, Bussel JB, George JN, McMillan R, Okano GJ, Nichol JL. A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation. Health Qual Life Outcomes. 2007;5:11. 6. Cooper N, Kruse A, Kruse C, et al. Immune thrombocytopenia (ITP) World Impact Survey (I-WISh): impact of ITP on health-related quality of life. Am J Hematol. 2021;96(2):199-207. 7. Marrie RA, Fisk JD, Dolovich C, et al. Psychometric performance of fatigue scales in inflammatory bowel disease. Inflamm Bowel Dis. 2024;30(1):53-63. 8. Cella D, Yount S, Sorensen M, Chartash E, Sengupta N, Grober J. Validation of the functional assessment of chronic illness therapy fatigue scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol. 2005;32(5):811-819.
MAT-GLB-2500852-v1.0-06/2025