<table border="1" cellpadding="1" cellspacing="1" style="width:100%;">
 <tbody>
 <tr>
 <td colspan="3" style="background-color: rgb(244, 242, 246);">
 Bi-hormonal CL systems 
 (Systems delivering both Insulin and glucagon)</td>
 </tr>
 <tr>
 <td style="background-color: rgb(244, 242, 246);">Strategies</td>
 <td style="background-color: rgb(244, 242, 246);">Advantages</td>
 <td style="background-color: rgb(244, 242, 246);">Limitations</td>
 </tr>
 <tr>
 <td>Glucagon helps in minimizing the impact of the delayed onset in insulin action by counteracting the persisting glucose-lowering effects of insulin</td>
 <td>
 <ul>
 <li>
 Bypass limitations of SC route</li>
 <li>
 Improved time-in-range</li>
 <li>
 Less hypoglycemia during excercise</li>
 </ul></td>
 <td>
 <ul>
 <li>
 Stability and cost</li>
 <li>
 Long-term safety of glucagon</li>
 <li>
 Increased complexity of the system</li>
 </ul></td>
 </tr>
 </tbody>
</table>

BI hormonal CL systems

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Bi-hormonal CL systems (Systems delivering both Insulin and glucagon)
Strategies	Advantages	Limitations
Glucagon helps in minimizing the impact of the delayed onset in insulin action by counteracting the persisting glucose-lowering effects of insulin	Bypass limitations of SC route Improved time-in-range Less hypoglycemia during excercise	Stability and cost Long-term safety of glucagon Increased complexity of the system

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