- Article
- Source: Campus Sanofi
- May 20, 2025
ROLE OF ECG IN DIFFERENTIAL DIAGNOSIS OF ANDERSON–FABRY DISEASE WITH HCM
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Study objective and method
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Determine independent ECG predictors of AFD
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Validate an ECG scoring system for differential diagnosis of AFD
Results
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Anderson–Fabry ECG score
Score calculation | PR interval | <120 ms | 1 |
| 120- 199 ms | 0 | ||
| ≥200 ms | 2 | ||
| QRS duration | <100 ms | 0 | |
| 100–119 ms | 1 | ||
| 120–139 ms | 2 | ||
| ≥140 ms | 3 | ||
| RBBB (complete and incomplete) | Yes | 2 | |
| No | 0 | ||
| R in aVL ≥11 mV | Yes | 1 | |
| No | 0 | ||
| Inferior ST-segment depression | Yes | 3 | |
|
No | 0 |
Algorithm for step-by–step analysis of the ECG for AFD
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Conclusion
Independent predictors of AFD diagnosis
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Short PR interval
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Prolonged QRS duration
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RBBB
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R in aVL ≥1.1 mV
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Inferior ST-segment depression
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A stepwise ECG scoring system
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Good
diagnostic performance
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Discriminates unexplained LVH
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Providing clinical and therapeutic implications
AFD: Anderson–Fabry disease; aVF: Augmented vector foot; aVL: Augmented vector left; ECG: Electrocardiogram; HCM: Hypertrophic cardiomyopathy; LVH: Left ventricular hypertrophy; MS: Millisecond; mV: Millivolt; RBBB: Right bundle branch block.
MAT-BH-2400131-V1-March 2024