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This video outlines the development process for Nexviadyme®. Find out how we used preclinical mice models of Pompe to help design Nexviadyme®, and ultimately, improve maintenance of muscle strength compared to Myozyme®.1,2

Our commitment to rare diseases

Find out how we have led with science for over 30 years,and continue to bring innovation to people living with lysosomal storage disorders.

Why Nexviadyme®  was developed

From the challenges of cell delivery, to optimising targeting,2,4 explore why Sanofi developed Nexviadyme®.

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Our commitment to rare diseases

Find out how we have led with science for over 30 years,and continue to bring innovation to people living with lysosomal storage disorders.

Why Nexviadyme®  was developed

From the challenges of cell delivery, to optimising targeting,2,4 explore why Sanofi developed Nexviadyme®.

References
  1. Sanofi. Nexviadyme (avalglucosidase alfa). Summary of Product Characteristics. 2023. Available at: https://www.medicines.org.uk/emc/product/14562/smpc#gref.
  2. Zhu Y, et al. Glycoengineered acid alpha-glucosidase with improved efficacy at correcting the metabolic aberrations and motor function deficits in a mouse model of Pompe disease. Molecular Therapy. 2009 Jun;17(6):954-963.

  3. Mistry, P.K. et al. Rare lysosomal disease registries: lessons learned over three decades of real-world evidence. Orphanet Journal of Rare Diseases. 2022;17:362.
  4.  Zhu Y, et al. Carbohydrate-remodelled acid alpha-glucosidase with higher affinity for the cation-independent mannose 6-phosphate receptor demonstrates improved delivery to muscles of Pompe mice. The Biochemical Journal. 2005 Aug 1;389(Pt 3):619-628.

  5. Chien YH, et al. Long-term prognosis of patients with infantile-onset Pompe disease diagnosed by newborn screening and treated since birth. Journal of Pediatrics. 2015 Apr;166(4):985-91.e1-2.

MAT-XU-2302278 (v2.0) Date of preparation: November 2023