<a href="${link:{uuid:{d4dafd48-4837-4ef7-ab1b-76db53f754ab},repository:{dam},path:{/Portal/UK/Prescribing-links/Dupixent%20(COPD)%20PI%20GB%20September%202024.pdf}}}" target="_blank">Dupixent (dupilumab) Prescribing Information (GB only)</a>

<h2>COPD exacerbation risk has been shown to accelerate after each exacerbation.2,a&nbsp;</h2>
<h3>Exacerbation risk accelerates after each exacerbation2</h3>

*Severe exacerbations were defined as those which resulted in hospitalisation with a primary discharge diagnosis of COPD2
<h3>Despite triple inhaled therapyc, many patients remain symptomatic as defined by persistent symptoms and exacerbations.2</h3>

<h2>COPD exacerbations may lead to an accelerated rate of decline in lung function3,d</h2>

<ul>
 <li>
 Rate of FEV1 decline nearly double3</li>
 <li>
 Lung function decline may occur after only one COPD exacerbation3</li>
</ul>

aBased on data from a large population-based cohort of 73,106 Canadian patients (mean age 75 years) who were hospitalised for the first time because of a severe exacerbation of COPD (1990-2005, followed until death or March 31, 2007). The hazard functions of successive hospitalised COPD exacerbations and all-cause mortality over time were estimated, and HRs adjusted for age, sex, calendar time and comorbidity.&nbsp;2 bAdjusted for age, sex, calendar time, and the modified Chronic Disease Score.2 cOr double inhaled therapy if ICS is contraindicated.4 dFEV1 decline after a single moderate-to-severe exacerbation. Based on a retrospective analysis of data from 586 patients with moderate-to-severe COPD.3&nbsp; 
 aHR, adjusted hazard ratio; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 second; QoL, quality of life&nbsp;

Dupixent (dupilumab) Prescribing Information (GB ONLY)

CHRONIC-OBSTRUCTIVE-PULMONARY-DISEASE-(COPD)

RESPIRATORY

The impact of exacerbations in COPD

<a href="${link:{uuid:{d4dafd48-4837-4ef7-ab1b-76db53f754ab},repository:{dam},path:{/Portal/UK/Prescribing-links/Dupixent%20(COPD)%20PI%20GB%20September%202024.pdf}}}" target="_blank">Dupixent (Dupilumab) Prescribing Information (GB only)</a>

<h2>The SGRQ measures the qualitative impact of COPD1,2</h2>
Some domains evaluated by the SGRQ include1,2:

Cough

Sputum production

Breathlessness

Wheezing

Exacerbations

Work activities

Daily activities*

Medication use

*Such as walking upstairs or getting dressed.
<h3>E-RS:COPD assess COPD symptoms3,4,b</h3>
Some domains evaluated by the E-RS:COPD include3,4:

Breathlessness

Cough &amp; Sputum&nbsp;

Chest symptoms

Additional Attributes (tired or weak, sleep disturbance, scared or worried)

<h4>This is not an exhaustive list of items evaluated by the SGRQ and E-RS:COPD.</h4>

a The SGRQ is a 50-item questionnaire designed to measure the qualitative impact of COPD on overall health , daily life, and perceived well-being. Higher scores mean greater disease severity.1,2 b E-RS:COPD is an 11-item patient-reported derivative tool that measures the effect of treatment on respiratory symptom severity in patients with stable COPD . Higher scores mean greater disease severity. 3,4
 
 COPD, chronic obstructive pulmonary disease; E-RS:COPD, Evaluating Respiratory Symptoms in COPD; QoL, quality of life; SGRQ, St George’s Respiratory Questionnaire

Dupixent (Dupilumab) Prescribing Information (GB ONLY)

Quality of life and symptom measurement in COPD patients

<a href="${link:{uuid:{41d82ab0-c017-4e79-be57-e5930764c364},repository:{dam},path:{/Portal/UK/Prescribing-links/Rezurock%20PI%20GB.pdf}}}" target="_blank">Prescribing Information Rezurock belumosudil (tablets)</a>

<h2>Patient impact and treatment goals of cGvHD</h2>
Patients with cGvHD experience a range of physical, functional, psychosocial, and economic 
 deficits.1-3&nbsp;Preventing disease progression and irreversible damage are critical goals in the management of cGvHD.&nbsp;

The inflammation and fibrosis associated with cGvHD can lead to multiple physical ailments impacting numerous organs.4-6

Psychological distress is associated with worsening QoL, physical function and cGvHD symptom burden.7

Only 37.5% of patients with cGvHD are able to return to work.8-9&nbsp;This is associated with decreased QoL, activity level and physical and mental functioning.

Download a summary of the affect that cGvHD has on patients and explore how their quality of life can be impacted. (For full interactivity, download&nbsp;and view in Adobe Acrobat).

TRANSPLANT

Dawn Hart, Katharina Ecsy, Luke Skinner, Arunesh Sil, Richard Hudson and Matthew Bradberry

This poster presents a qualitative study on how cGvHD affects the QoL for patients and their caregivers. It highlights the major challenges faced, especially after multiple failed treatments. The study, based on interviews with patients and caregivers, examines the physical, emotional, social and financial burdens of cGvHD. Key findings include the disease's impact on daily life, the added strain from treatment side effects, and the psychological and financial toll.

Dawn Hart, Katharina Ecsy, Luke Skinner, Arunesh Sil, Richard Hudson and Matthew Bradberry
This poster showcases a quantitative study on how cGvHD affects the QoL for patients and their caregivers. It reveals the severe physical symptoms, heavy treatment burden, and emotional challenges for patients, along with the significant anxiety and financial strain for caregivers. The study highlights the urgent need for better support and management strategies to improve quality of life for both patients and caregivers.

Abbreviations

References

REZUROCK®▼ (belumosudil) Prescribing Information (GB ONLY)

cGvHD Quality of Life

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The impact of exacerbations in COPD

Quality of life and symptom measurement in COPD patients

cGvHD Quality of Life