Levels Matter

Factor VIII Infusion, Dosing and Administration for Hemophilia A

Types of Infusions for Treatment of Hemophilia

Hemophilia is an inherited bleeding disorder caused by a deficiency of either clotting factor VIII (hemophilia A) or IX (hemophilia B), leading to impaired blood clotting and an increased risk of prolonged or spontaneous bleeding. Clotting factor therapy, which involves intravenous administration of factor VIII or IX, restores the clotting and remains a cornerstone of hemophilia management.^1,2 While other treatments are available, this article focuses specifically on clotting factor replacement delivered through intravenous infusion.

Factor VIII Deficiency and Hemophilia A: Understanding High and Low Factor Activity Levels

Hemophilia A is a bleeding disorder caused by Factor VIII (FVIII) deficiency, with severity linked to FVIII activity levels. This article explores FVIII biology, defines activity ranges, and reviews current approaches to replacement therapy.

Factor VIII Activity Assays - A Guide to PK Testing

Pharmacokinetic (PK) testing with accurate Factor VIII assays may help personalize hemophilia A treatment.^1,2 This article reviews one-stage and chromogenic methods and their clinical use.

The Risk of Factor VIII Inhibitors in Hemophilia A Treatment

Factor VIII (FVIII) replacement therapies have been a step forward for the prevention and treatment of bleeding episodes in patients with hemophilia A. One remaining challenge is the development of neutralizing antibodies, known as inhibitors, which interfere with patient response to a factor infusion or render it ineffective.

Hemophilia A in Women - Key Points to Discuss With Your Patients

Hemophilia A–a rare bleeding disorder–often goes undiagnosed in women because of the misconception that it only affects men, due to its X-linked recessive inheritance pattern. Although factor levels above 50% are usually considered within the normal range, emerging data suggest that some women and girls with levels between 50% and 60% may still have an increased risk of bleeding symptoms. Additionally, they may have sex-specific symptoms such as heavy menstrual bleeding and postpartum hemorrhage. This highlights the need for a more nuanced understanding of hemophilia A as it pertains to women.

Exploring Factor VIII Replacement Therapies: A Guide to Choosing the Right Treatment for Patients With Hemophilia A

Ensuring optimal care for patients with hemophilia A requires a thorough understanding of available treatment options, prioritization of bleed prevention and long-term joint health, and comprehensive patient education. This article will cover different types of factor VIII replacement therapies^* and will compare an on-demand versus prophylactic treatment approach with the goal of helping tailor treatment plans effectively, which can help enhance quality of life.