Titration Inertia; A Predominant Issue for People with Diabetes

Low number of people with diabetes, using insulin, are achieving glycemic control

*Target HbA1c <7%; The IDMPS (N=1936) was a large, observational study program, collating data in seven individual waves from 2005 to 2017. The data from wave 7 (2016–2017) describing real-world acheivement of glycemic targets was reported in this study HCPs, Healthcare practitioners; OADs, oral antidiabetic drugs; T2DM, type 2 diabetes mellitus

Once basal insulin has been initiated, titration inertia can become a predominant issue for people with diabetes

Real-world evidence indicates that the structured and monitored titration algorithms that are applied in randomized controlled trials are not reflective of behavior in practice

Fear of hypoglycemia is a major barrier to insulin initiation and optimal insulin titration

Careful titration of insulin therapy can achieve glycemic control without a significant risk of hypoglycemia¹; however, in clinical practice, fear of hypoglycemia is a common barrier to optimal titration, concordance and achieving glycemic targets with insulin^1–3

Titration is a critical phase for basal insulin, and imperative for success of therapy

Difference in dose usage controlled Clinical Studies reality vs Real Life 45-75% of Basal T2 patients are uncontrolled and below optimal BI dose by as much as 30%.

Contact frequency determines outcome of basal insulin initiation trials.