This website contains promotional content and is intended for Healthcare Professionals based in the United Kingdom only. Some content is only relevant to HCPs practising in Great Britain (England, Scotland, Wales). This website is optimised for desktop use, and some features may perform differently on mobile devices.

Adverse event reporting can be found at the bottom of the page.

Praluent logo

In patients with a prior cv event, Praluent® (alirocumab) significantly reduced the risk of MACE (primary endpoint) in patients already on high intensity statins1,2

~90% of patients in ODYSSEY OUTCOMES were on high-intensity statins1

Study design: ODYSSEY OUTCOMES was a randomized, double-blind, placebo-controlled phase 3 study. Patients with a recent MI or unstable angina, and on high-intensity statin (40 or 80 mg atorvastatin or 20 or 40 mg rosuvastatin, or maximally tolerated dose of one of these agents) +/- other lipid-lowering therapy but not at predefined target LDL-C were enrolled.1


In patients with a prior CV event, Praluent® demonstrated a significant reduction in the risk of MACE for the overall trial population vs placebo, HR 0.85 [95% CI 0.78 - 0.93] p=0.0003).2

A greater absolute benefit was observed in patients with baseline ≥2.6 mmol/L LDL-C (non-prespecified analysis).2

See Kaplan-Meier curves for MACE

Overall efficacy in main CV outcomes

Praluent® provided consistent results across CV outcomes1
Among the main secondary endpoints, the risks of any CHD event (including CHD death, nonfatal MI, UA requiring hospitalisation, and an ischaemia-driven coronary revascularisation procedure), major CHD event (including death from CHD and nonfatal MI), CV event (including nonfatal MI and nonfatal ischaemic stroke), and a composite of death from any cause, nonfatal MI or nonfatal ischemic stroke were significantly lower among patients treated with Praluent® than those who received placebo.1

View table and forest plot of CV outcome results

All-cause mortality

Praluent® was associated with a reduction of all-cause mortality (nominal significance by hierarchical testing) for the overall trial population vs placebo, HR 0.85 [95% CI 0.73–0.98]2,3.

In a post-hoc analysis, a greater benefit was observed in patients with baseline 100 mg/dL LDL-C for the overall trial population vs placebo, HR 0.71 [95% CI 0.56–0.90].2,3**

**Post-hoc analysis.

ACS=acute coronary syndrome; ARR=absolute risk reduction; CHD=coronary heart disease; CI=confidence interval; CV=cardiovascular; HCL-C=high-density lipoprotein cholesterol; HR=hazard ratio; LDL-C=low-density lipoprotein cholesterol; MACE=major adverse cardiac events (primary composite endpoint of CHD death, nonfatal myocardial infarction, fatal and nonfatal ischaemic stroke, or unstable angina requiring hospitalization); MI=myocardial infarction; NNT=number needed to treat; PCSK9i=proprotein convertase subtilisin/kexin type 9 inhibitor; RRR=relative risk reduction.

View forest plot for all-cause mortality


Find more information on Indication, Administration and Mechanism of Action and watch videos about Praluent®.

Patient Website

Find resources and support for your patients on Praluent®. Find useful links about how patients can manage their cholesterol.

Get in touch with the Dyslipidaemia Team

  1. Schwartz G, et al. N Engl J Med 2018;379:2097–2107.
  2. Praluent Summary of Product Characteristics. Available at Accessed October 2023.
  3. Schwartz G, et al. N Engl J Med 2018;379:2097–2107. Supplementary Appendix.

MAT-XU-2204592 (v3.0) Date of Preparation: October 2023