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Praluent logo

Praluent® is a fully human monoclonal antibody1 that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) from binding to LDL-Rs, increasing the number of LDL-Rs available to remove LDL-C from the circulation.1,2

Without PCSK9 inhibition, PCSK9 decreases the number of available LDL-Rs on liver cells, resulting in higher LDL-C levels in the bloodstream.1

PCSK9 inhibition with Praluent® increases the number of available LDL-Rs, resulting in lower LDL-C levels in the bloodstream.1

Figure © Sanofi.

Watch the video below to learn more about the mechanism of action for Praluent®


Find more information on Indication, Administration and Mechanism of Action and watch videos about Praluent®.

Patient Website

Find resources and support for your patients on Praluent®. Find useful links about how patients can manage their cholesterol.

Get in touch with the Dyslipidaemia Team

LDL-C=low-density lipoprotein cholesterol; LDL-R=low-density lipoprotein receptor; PCSK9i=proprotein convertase subtilisin/kexin type 9 inhibitor.

  1. Praluent Summary of Product Characteristics. Available at Accessed October 2023.
  2. Poirier S and Mayer G. Drug Des Devel Ther 2013;7:1135–1148.

MAT-XU-2204608 (v3.0) Date of Preparation: October 2023