Step into The Betaverse and uncover the hidden world of beta cells. The film explores the mechanisms of autoimmune type 1 diabetes (T1D) and brings to life the crucial role of beta cells in maintaining glucose homeostasis. Learn more about these cells that not only produce insulin but also keep the entire system in harmony.
The ongoing paradigm shift in autoimmune type 1 diabetes (autoimmune T1D) care with early screening and risk monitoring can now help identify people at risk in the pre-symptomatic stages.1 The HCPs can be instrumental in enabling this shift by supporting knowledge dissemination and clinical application by early screening of autoimmune T1D.1,2 This approach ensures that benefits are realized by patients and caregivers at the early stage of autoimmune T1D.1,2
Early screening for islet autoantibodies in type 1 diabetes (T1D) in children and adolescents can effectively identify individuals at a higher risk of developing autoimmune T1D.1
Psychological issues in autoimmune patients with type 1 diabetes (T1D) impact glycemic control, increase the risk of cardiovascular complications, contribute to comorbid psychosocial conditions, and reduce overall quality of life.1 Early screening for genetic risk factors and beta-cell autoantibodies helps prevent severe complications, such as diabetic ketoacidosis (DKA) and ensures timely access to crucial psychosocial support.2
People with autoimmune type 1 diabetes (autoimmune T1D) often present with acute symptoms of diabetes, markedly elevated blood glucose levels and 25–50% are diagnosed with life-threatening diabetic ketoacidosis (DKA).1 However, autoimmune T1D is a progressive disease that progresses through distinct stages before clinical symptoms are observed.2,3 Early T1D detection is possible; by identifying autoimmune T1D early, you can significantly lower the risk of DKA at diagnosis.4
Understanding T1D means recognising the value of beta cells.
Autoimmune type 1 diabetes (autoimmune T1D) is a progressive autoimmune disorder that causes the destruction of insulin-producing beta cells in the pancreas, leading to an inability to regulate blood glucose levels.1 Understanding the pathophysiology of autoimmune T1D can help identify potential at-risk patients and facilitate early intervention.2
The causes and risk factors of autoimmune type 1 diabetes (autoimmune T1D) are multifactorial. A combination of genetic susceptibility and other risk factors, like a family history of autoimmune disease, increase the risk of developing the pathology.1,2 Identifying these risk factors can help HCPs proactively screen high-risk patients and help avoid serious complications through targeted interventions.3
Early screening for type 1 diabetes autoantibodies enables the identification of individuals at risk before symptoms appear, allowing for timely intervention and disease management.1 Anti-islet autoantibodies that target proteins associated with beta-cells serve as biomarkers of autoimmune type 1 diabetes (autoimmune T1D) development.2 The number of detectable autoantibodies through screening correlates with the risk of developing autoimmune T1D.2 Assays for detecting autoimmune T1D have shown high sensitivity and specificity.3