IL-4, IL-13, AND IL-5 ARE DRIVERS OF SYSTEMIC TYPE 2 INFLAMMATION

IL-4 and IL-13 traffic EOS directly to airway tissues, leading to asthma symptoms and increasing the risk of exacerbations and lung function decline.

IL-5 promotes the trafficking, differentiation, release, and survival of EOS.

Th2 cell differentiation^1,2 

Asthma triggers can activate the alarmin pathway while concurrently activating dendritic cells directly, which differentiate Th0 cells into Th2 cells and, along with ILC2 cells, produce IL-4, IL-13, and IL-5.