<p>Prescribing Information can be found through the links in the Product Cards at the bottom of the page</p>

<h3>Toujeo®&nbsp; versus insulin glargine 100 units/mL in T1DM</h3>
<p>EDITION 4, EDITION JUNIOR and EDITION JP1 - meta-a<span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif">nalysis<sup>1,8-10&nbsp; &nbsp; &nbsp; &nbsp; </sup></span></span></span></p>
<p style="margin-bottom:11px"><span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif">All individual trials met their primary endpoints: change in HbA<sub>1c </sub>from baseline to Week 26<b><sup>8-10</sup></b></span></span></span></p>

TYPE-1-DIABETES

DIABETES

<p>DOWNLOAD A COMPREHENSIVE SUMMARY OF THIS T1DM META-ANALYSIS</p>

<p>Clinical summary to read about the benefits of Toujeo<sup>&reg;</sup> in children and adolescents from the age of 6 years in this randomised trial</p>


<p>This slide deck can be used to support Health Care Professional training on Toujeo. It provides an overview of clinical studies T1 Edition Junior and Meta-Analysis</p>


Safety Profile

Abbreviations

<table border="1" cellpadding="1" cellspacing="1">
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    <p><a href="${link:{uuid:{acd7760d-f31d-4d7e-8b21-2cdf496d1cc2},repository:{dam},path:{/Portal/UK/Prescribing-links/Lantus_GB_NI.pdf}}}">Prescribing Information&nbsp;UK</a><br>
      &nbsp;</p>
    <p data-font="small">&nbsp;</p></td>
  </tr>
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<table border="1" cellpadding="1" cellspacing="1">
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    <p><a href="${link:{uuid:{8cd02cf2-bd72-495f-b720-698ef8d3f0da},repository:{dam},path:{/Portal/UK/Prescribing-links/Toujeo.pdf}}}" target="_blank">Prescribing Information UK</a><br>
      &nbsp;</p>
    <p data-font="small">&nbsp;</p></td>
  </tr>
 </tbody>
</table>

Toujeo (insulin glargine 300 Units/mL) Versus insulin glargine 100 units/mL in T1DM

Lantus® (insulin glargine 100 units/mL) Prescribing Information UK

Toujeo® (insulin glargine 300 units/mL) Prescribing Information UK

<h3>Toujeo® versus insulin degludec 100 units/mL in T2DM</h3>
<p><br>
  BRIGHT - randomised, active-controlled, open-label study<sup>6,17</sup></p>

TYPE-2-DIABETES

<p>DOWNLOAD A COMPREHENSIVE SUMMARY OF THE BRIGHT STUDY &gt;</p>

Toujeo (insulin glargine 300 Units/mL) Versus insulin degludec 100 units/mL in T2DM

<p>In this 7-minute video Dr. Alice Cheng tells you about the BRIGHT study, the head-to-head trial comparing Toujeo<sup>®</sup> vs insulin degludec 100 units/mL meeting the primary endpoint. She tells about the results and why they are relevant and important to her clinical practices, in helping the right patients on the right treatment.​</p>

<p>This slide deck can be used to support Health Care Professional training on Toujeo. It provides clinical evidence of Toujeo in vulnerable patients.​</p>


<p>This slide deck can be used to support Health Care Professional training on Toujeo. It provides an overview of clinical studies including the Bright Study.​</p>


<table border="1" cellpadding="1" cellspacing="1" style="width:500px;">
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   <td>
    <p><a href="${link:{uuid:{acd7760d-f31d-4d7e-8b21-2cdf496d1cc2},repository:{dam},path:{/Portal/UK/Prescribing-links/Lantus_GB_NI.pdf}}}">Prescribing Information&nbsp;UK</a><br>
      &nbsp;</p>
    <p>&nbsp;</p></td>
  </tr>
 </tbody>
</table>

<table border="1" cellpadding="1" cellspacing="1" style="width:500px;">
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   <td>
    <p><a href="${link:{uuid:{8cd02cf2-bd72-495f-b720-698ef8d3f0da},repository:{dam},path:{/Portal/UK/Prescribing-links/Toujeo.pdf}}}" target="_blank">Prescribing Information UK</a><br>
      &nbsp;</p>
    <p data-font="small">&nbsp;</p></td>
  </tr>
 </tbody>
</table>

Lantus® (insulin glargine 100 units/mL) Prescribing Information GB

Lantus® (insulin glargine 100 units/mL) Prescribing Information NI

<h3>Toujeo® versus insulin degludec 100 units/mL in T1DM</h3>
<p>InRange - randomised, active-controlled, open-label study<sup>4,5&nbsp;</sup></p>
<p>Primary endpoint was met: non-inferiority to insullin degludec 100 units/mL for time in range (TIR)&nbsp;<span style="font-size:11pt"><span style="line-height:107%"><span style="font-family:Calibri,sans-serif">≥70 to ≤180 mg/dL (≥3.9 to ≤10 mmol/L) at Week 12<sup>5</sup></span></span></span></p>

<p>DOWNLOAD A COMPREHENSIVE SUMMARY OF THE INRANGE STUDY &gt;</p>

Toujeo (insulin glargine 300 Units/mL) Versus insulin degludec 100 units/mL in T1DM

<p>Professor Richard Bergenstal presents the results of the InRange study. This study is the first randomised controlled trial to compare second generation basal insulin analogues Toujeo® and insulin degludec 100 U/mL. It compares adults with T1DM using Time-In-Range (TIR) as the primary endpoint. Watch and learn about the study design and key findings</p>

<p>View the guide to find out more about the impact of time in range on your patients</p>


<table border="1" cellpadding="1" cellspacing="1" style="width:500px;">
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    <p><a href="${link:{uuid:{acd7760d-f31d-4d7e-8b21-2cdf496d1cc2},repository:{dam},path:{/Portal/UK/Prescribing-links/Lantus_GB_NI.pdf}}}">Prescribing Information&nbsp;UK</a></p>
    <p>&nbsp;</p></td>
  </tr>
 </tbody>
</table>

<table border="1" cellpadding="1" cellspacing="1">
 <tbody>
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   <td>
    <p><a href="${link:{uuid:{8cd02cf2-bd72-495f-b720-698ef8d3f0da},repository:{dam},path:{/Portal/UK/Prescribing-links/Toujeo.pdf}}}" target="_blank">Prescribing Information UK</a></p>
    <p>&nbsp;</p></td>
  </tr>
 </tbody>
</table>

<h4>Would you like to discuss anything about our products with your Haemato-oncology sales specialist? Or want support in ordering Oncology patient materials?</h4>
<p>Leave your request and contact details and we'll get back to you shortly.</p>
<p>For all product-related medical enquiries, please contact Medical Information via&nbsp;<a href="http://www.sanofi.co.uk/en/about-us/sanofi-in-the-uk/contact-us" target="_blank">this link</a>&nbsp;or call +44 (0) 800 035 2525 (Monday - Friday, 08:30 - 17:30, excluding public holidays).</p>

Get in Touch with the Haemato-oncology Team

OTHER-ONCOLOGY-TOPICS

ONCOLOGY

<p>Prescribing Information for SARCLISA<sup>®</sup>▼&nbsp;(isatuximab) can be found via the Product Card at the bottom of the page.</p>

<table border="1" cellpadding="1" cellspacing="1" style="width: 100%;">
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   <td>
    <h3><strong>Multiple myeloma is a blood cancer accounting for 2% of cancers in the United Kingdom.<sup>1</sup></strong></h3>
    <p>Despite available treatments, multiple myeloma remains an incurable malignancy and is associated with significant patient burden, with patients relapsing over time.<sup>2&nbsp;</sup>As they relapse, patients can become refractory/resistant to treatments.<sup>3</sup></p></td>
  </tr>
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   <td>
    <h3><strong>Sanofi Oncology is committed to the management of patients with multiple myeloma.</strong></h3>
    <p>SARCLISA<sup>®&nbsp;</sup>(isatuximab) is indicated:</p>
    <p>In combination with pomalidomide and dexamethasone, for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor and have demonstrated disease progression on the last therapy.</p>
    <p>In combination with carfilzomib and dexamethasone, for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.<sup>4</sup></p></td>
  </tr>
 </tbody>
</table>

<h2>Relapsed Refractory Multiple Myeloma Product</h2>

<p><a href="http://pro.campus.sanofi/uk/products/sarclisa">Learn more&nbsp; →</a></p>

<p><a href="https://pro.campus.sanofi/dam/jcr:6de3a21b-b60e-4a56-afea-e43468d285d6/Sarclisa%20PI%20GB%20May%202024_campus.pdf">Prescribing information UK</a></p>

<p data-font="small">MAT-XU-2202578 (v5.0)<br>
  Date of preparation: January 2025</p>
<p data-font="small">▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.</p>

About Multiple Myeloma

SARCLISA®▼ (isatuximab) Prescribing Information UK

MULTIPLE-MYELOMA

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