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AVAXIM® JUNIOR

hepatitis A vaccine (inactivated, adsorbed)

AVAXIM® Junior is indicated for active immunisation against infection caused by hepatitis A virus (HAV) in children aged 1 - 15 years.1

Before you prescribe this vaccine please refer to the Prescribing Information and SmPC link. The use of Avaxim Junior should be based on official recommendations.

Summary

Fast

  • AVAXIM Junior provides rapid seroprotection against hepatitis A as early as two weeks from the first dose.1
  • 14 days after the first dose of vaccination more than 94% of immunocompetent individuals are protected.*2

Flexible

  • AVAXIM Junior is interchangeable with other paediatric inactivated hepatitis A vaccines as a booster with flexible booster timing.1
  • The booster dose can be given between 6 months and 15 years after the first dose.1

Effective

  • AVAXIM Junior offers long-lasting protection against Hepatits A, up to 15 years after initial immunisation.†1,3

*Seroconversion defined as anti-HAV antibody titres rising from <20 mlU/ml (seronegative) to ≥20 mIU/ml. Monocentric, open trial evaluating Avaxim in children aged 18 months – 3 years (n=37), 4 – 8 years (n=53) and 9-15 years (n=83). Two weeks after the first dose, seroconversion was achieved by 94.6% of initially HAV-seronegative subjects aged 18 months – 3 years, 94.3% of subjects aged 4-8 years and 96.4% of subjects aged 9-15 years.2

One study was conducted in children (N=54) aged 12 through 47 months vaccinated with 2 doses of the vaccine 6 months apart. The results showed a persistence of the antibodies for a period up to 14-15 years at levels considered as protective and do not suggest a need for new administration of the vaccine. A statistical model using the available data from this study until 14-15 years after the administration of the 2 doses of the vaccine predicts a persistence of the protective anti-HAV antibodies for at least 30 years in 87.5% of these children (estimated prediction within the 95% confidence interval CI[74.1; 94.8]).3 Another long-term persistence study was conducted in Argentina with children aged between 11 and 23 months at the time of inclusion. All children had received routine vaccination with 1 dose (Group 1: N = 436) or 2 doses (Group 2: N = 108) of hepatitis A vaccine. After 15 years of follow-up, all remaining subjects showed anti HAV antibodies concentration ≥10 mIU/mL (using ATELLICA) indicative of seroprotection for up to 15 years after 1 or 2 doses. Statistical modelling using data from HAF82 (covering Year 0 to Year 15) including natural boosting effect, predicts that 94% [89-98] of subjects having received one vaccine dose and 93% [88-97] of subjects having received two vaccine doses will have anti-HAV titers above the threshold for seroprotection for up to 40 years after the first administration.4

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References
  1. Avaxim Junior Summary of Product Characteristics
  2. Dagan R, et al. Vaccine. 1999;17(15-16):1919-25
  3. López, E. L, et al. Pediatr Infect Dis J. 2015;  34(4), 417-425.
  4. Espul, C, et al. Vaccine 2020;38(4):858-865.

MAT-XU-2301296 (v6.0) Date of preparation: August 2025