There's a Beta Way to look at type 1 diabetes
Understanding T1D means recognising the value of beta cells.
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The pathophysiology of autoimmune type 1 diabetes
Autoimmune type 1 diabetes (autoimmune T1D) is a progressive autoimmune disorder that causes the destruction of insulin-producing beta cells in the pancreas, leading to an inability to regulate blood glucose levels.1 Understanding the pathophysiology of autoimmune T1D can help identify potential at-risk patients and facilitate early intervention.2
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Etiology and risk factors for autoimmune type 1 diabetes
The causes and risk factors of autoimmune type 1 diabetes (autoimmune T1D) are multifactorial. A combination of genetic susceptibility and other risk factors, like a family history of autoimmune disease, increase the risk of developing the pathology.1,2 Identifying these risk factors can help HCPs proactively screen high-risk patients and help avoid serious complications through targeted interventions.3
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Screening for autoimmune type 1 diabetes using autoantibodies
Early screening for type 1 diabetes autoantibodies enables the identification of individuals at risk before symptoms appear, allowing for timely intervention and disease management.1 Anti-islet autoantibodies that target proteins associated with beta-cells serve as biomarkers of autoimmune type 1 diabetes (autoimmune T1D) development.2 The number of detectable autoantibodies through screening correlates with the risk of developing autoimmune T1D.2 Assays for detecting autoimmune T1D have shown high sensitivity and specificity.3
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The role of antibodies and autoantibodies in autoimmune type 1 diabetes
B cells produce autoantibodies against pancreatic islet cells months and even up to years before the onset of clinically relevant symptoms of autoimmune type 1 diabetes (autoimmune T1D), providing an opportunity for early detection and potential prevention of autoimmune T1D onset.1-2 These type 1 diabetes (T1D) autoantibodies serve as important biomarkers for the development and progression of autoimmune T1D.1
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Real-life stories from people living with autoimmune T1D
The progression of autoimmune type 1 diabetes (T1D) is gradual, often detectable months or even years before symptoms arise.1–3 Through proactive screening, we can identify the condition well in advance.3 Meet our ambassadors living with autoimmune T1D and discover the risk factors to look out for when considering who to screen.
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Does your patient have an existing autoimmune condition? Check for autoimmune type 1 diabetes!
Individuals living with other associated autoimmune diseases like celiac disease or autoimmune thyroid disease, are at an increased risk of developing autoimmune type 1 diabetes (T1D) and should be appropriately screened.1-6
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Can autoimmune type 1 diabetes be detected years before symptom onset?
Autoimmune type 1 diabetes (T1D) is a progressive disease in which the decline in beta cell function usually begins months or sometimes years before clinical symptoms are observed.1–3 You can identify such patients at risk of developing autoimmune T1D before clinical symptoms are noticed by you or your patient.3
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Need to identify risk of developing autoimmune type 1 diabetes? Test for autoantibodies!
Anti-islet autoantibodies that target proteins associated with beta-cells serve as biomarkers of autoimmune type 1 diabetes (T1D) development.1 The number of detectable autoantibodies through screening correlates with risk of developing autoimmune T1D.2 Assays for detecting autoimmune T1D have shown high sensitivity and specificity.3,4
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