- Article
- Source: Campus Sanofi
- 29 Oct 2025
Practical Insulin Transition Guide for Nurses: Titration and Patient Support

Table of Contents
Foundation of Successful Insulin Transitions
When diabetes patients need to switch insulin products due to product discontinuations, nurses play an important role in supporting the transition process. This guide provides practical instructions for managing insulin transitions, including titration protocols and patient monitoring strategies.
Titration, Monitoring, and Education
Educating patients to ensure hypoglycaemia prevention, especially during the transition phase, is vital for ensuring adherence to any insulin regime.
This includes1:
Blood glucose self-monitoring
Dietary considerations
Injection techniques
Insulin self-titration
Hypoglycaemia management
Step-By-Step Transition Recommendations
By following a systematic approach to titration, monitoring, and patient education, nurses may support patients transitioning between insulin products while helping maintain appropriate glycaemic control throughout the process.
Step 1: Pre-transition planning and patient education
Before initiating the switch in patients prescribed a different insulin product, nurses should ensure that the patient understands the process and safety considerations. Healthcare systems can reduce medication errors associated with similar-looking insulin products through proper patient counseling. Patients should be encouraged to verify both the insulin product name and dosage during appointments, especially when changes are communicated by phone.2
Nurses can foster patient partnership in treatment decisions by providing support during insulin product transitions. Key areas for patient support include3:
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Clinical Evidence
Sharing clinical evidence supporting the switch approach.

Clear Explanations
Providing clear explanations for the transition through educational materials.
Medical Education
Offering medical education to support informed, patient-focused decisions.

Dose Conversion & Monitoring
Ensuring proper dose conversion (unit-to-unit) with consistent monitoring approaches.

Patient Preferences
Respecting patient preferences regarding insulin type and delivery device selection.
Step 2: Dosing and administration during the transition period
Initial start basal insulin dosing can be calculated using body weight
(0.1– 0.2 units/kg per day) while considering the patient's current glucose levels, followed by personalised dose adjustments.1 The approach involves beginning with basal insulin and adjusting doses systematically to reach personalised fasting glucose targets for each patient.1 Patients should always adhere to the specific recommendations and dosing instructions provided by their healthcare provider at the time of prescription.
Toujeo (insulin glargine U300) is a basal insulin for once-daily administration at any time of the day, preferably at the same time every day. When needed, patients can administer Toujeo up to 3 hours before or after their usual time of administration.1 This scheduling flexibility may help during transition periods when patients are adjusting to new treatment routines.
Step 3: Collaborative transition monitoring
Switching between basal insulin products requires careful monitoring of blood glucose during the transition period.4 Throughout this monitoring phase, nurses can help recognise indicators of glucose control changes and adjust care approaches accordingly.
Patient, family, and HCP education about hypoglycaemia represents another strategy. Additionally, expanding knowledge about glucagon administration for severe hypoglycaemia episodes benefits patients, families, and the broader community.5
Hypoglycaemia Education: Key Areas5
Symptom Recognition: Understanding the signs of low blood sugar.
Risk Factor Identification: Knowing what can cause hypoglycaemia.
Blood Glucose Self-Monitoring Techniques: Enabling timely intervention with food or glucose.
Step 4: Continuity of care
Ensuring safe insulin transitions may require a comprehensive approach that integrates improved surveillance with informed, patient-centered decision-making based on individualised benefit-risk assessments.1
Conclusion
Successful insulin product transitions require a systematic approach that combines clinical expertise with patient-centric care. You can help facilitate these transitions through titration protocols, consistent patient monitoring, and thorough education throughout the process.
Patient education is an important component of transitions, encompassing not only technical aspects of insulin administration but also enabling patients and their families to recognise and respond appropriately to potential complications, like risk of hypoglycaemia.1,5 The approach involving nurses, patients, and the healthcare team may help manage insulin product switches, with a focus on patient needs.
Through the application of these strategies, nurses may help support insulin product transitions while helping to maintain adequate glycaemic control and address potential risks for people with diabetes who require changes in their insulin therapy.
Explore More
- Davies MJ, et al. Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2022;45(11):2753-2786.
- Pogach L, Aron D. Balancing Hypoglycemia and Glycemic Control: A Public Health Approach for Insulin Safety. JAMA. 2010;303(20):2076-2077.
- Joshi SR, et al. Biosimilars and interchangeable biosimilars: facts every prescriber, payor, and patient should know. Insulins perspective. Expert Opinion on Biological Therapy. 2023;23(8):693-704.
- U.S. Food and Drug Administration. Information regarding insulin storage and switching between products in an emergency. FDA. Published October 29, 2021. Accessed Sep 8, 2025.
https://www.fda.gov/drugs/emergency-preparedness-drugs/information-regarding-insulin-storage-and-switching-between-products-emergency - Ahrén B. Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes. Vascular Health and Risk Management. 2013;9:155-163.
MAT-XU-2503254-1.0-10/2025
