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Cause And Symptoms

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asthma

Asthma

Figure created with BioRender.com. aDaily OCS use &nbsp;bIn patients with asthma, mucus plugging is primarily driven by type 2 inflammation; however, type 1 immune responses, including neutrophil involvement, may also contribute.1 
 CLC, Charcot–Leyden crystal; EC, epithelial cell; eDNA, extracellular DNA; EOS, eosinophils; EPO, eosinophil peroxidase; H2O2, hydrogen peroxide; IL, interleukin; ILC, innate lymphoid cell; MUC5AC, mucin 5AC; OCS, oral corticosteroids; ppFEV1, percent predicted forced expiratory volume in 1 second; Th, T-helper. 
 1. Aegerter H, Lambrecht BN. Annu Rev Pathol. 2023;18:387–409. 2. Tang M, et al. Am J Respir Crit Care Med. 2022;205:1036–1045. 3. Chan R, et al. Allergy Clin Immunol Pract. 2023;11:195–199. 4. Audousset C, et al. Respiratory Res. 2024;25:52. 5. Dunican EM, et al. Ann Am Thorac Soc. 2018;15:S184–191.

<h3>Mucus plug score has a strong negative association with lung function parameters such as FEV1 and FVC1–3</h3>

aCorresponding to the 18 bronchopulmonary segments present in most people. BD, bronchodilator; CT, computed tomography; FEV1, forced expiratory volume in 1 second; LSMD, least squares mean difference; ppFEV1, percent predicted forced expiratory volume in 1 second.&nbsp; 
 1. Jaramillo AM, et al. Allergol Int. 2024;73:375–381. 2. Dunican EM, et al. J Clin Invest. 2018;128:997–1009. 3. Tang M, et al. Am J Respir Crit Care Med. 2022;205:1036–1045. 4. <a href="https://www.fluidda.com/lung-imaging-fri/">https://www.fluidda.com/lung-imaging-fri/</a>. Accessed January 2025.&nbsp; 
 5. Castro M, et al. Lancet Respir Med. 2025. In press. doi:10.1016/S2213-2600(24)00362-X. 6. Huang BK, et al. JCI Insight. 2024;9(3):e174124. 7. Porsbjerg C, et al. ERS. 2024. Presentation OA3649. 
 To report any side effect(s): 
 Saudi Arabia: National Pharmacovigilance and Drug Safety Centre (NPC) 
 SFDA call center: 19999. &nbsp;E-mail: <a href="mailto:npc.drug@sfda.gov.sa">npc.drug@sfda.gov.sa</a>. Website: <a href="https://ade.sfda.gov.sa/">https://ade.sfda.gov.sa</a> 
 Full Prescribing Information is available upon request: SANOFI, Kingdom of Saudi Arabia, P.O. Box 9874, Jeddah 21423, K.S.A. 
 Tel: +966-12-669-3318, Fax: +966-12-663-6191 
 For Medical Information, Please contact: +966-12-669-3318, <a href="mailto:ksa.medicalinformation@sanofi.com">ksa.medicalinformation@sanofi.com</a>. For Pharmacovigilance, Please contact: +966-54-428-4797, <a href="mailto:ksa_pharmacovigilance@sanofi.com">ksa_pharmacovigilance@sanofi.com</a>. To report any product technical complaints, kindly contact <a href="mailto:quality.greatergulf@sanofi.com">quality.greatergulf@sanofi.com</a>
SANOFI, Level 3, One JLT, Jumeirah Lake Towers (JLT), DMCC, PO Box 53899, Dubai, UAE | Tel: +971 4 550 3600 | Fax: +971 4 5521050 
 For further Medical Information, please contact: For UAE ✆ 800 MEDICAL Toll-Free Number. For all Gulf Countries ✆+971 45 50 38 63 or email: <a href="mailto:medical-information.gulf@sanofi.com">medical-information.gulf@sanofi.com</a>. Full Prescribing Information is available upon request. To report adverse events please call: +971 561747001 or email <a href="mailto:Gulf.Pharmacovigilance@sanofi.com">Gulf.Pharmacovigilance@sanofi.com</a> 
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ASTHMA

The Role of Mucus Plugging in Asthma and Its Clinical Burden

This educational video examines the pathophysiological mechanisms underlying mucus plug formation in asthma and explores their clinical significance in airway obstruction. The presentation addresses how mucus plugging contributes to disease burden and persistent symptoms in asthmatic patients. Healthcare professionals will learn about the cellular and molecular processes involved in mucus hypersecretion and their impact on patient outcomes.

Understanding Airway Obstruction: The Role of Mucus Plugging in Asthmatic Disease

DERMATOLOGY

<h3 style="text-align:center;">Learn More About These Available Noninvasive Techniques for Assessment of Lung Function3-5</h3>

 Spirometry

Oscillometry

Body Plethysmography

1. Fuhlbrigge AL, et al. Pediatrics. 2006;118(2):e347-e355.&nbsp; 
 2. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. Updated May 2025. Accessed May 30, 2025. https://ginasthma.org/2025-gina-strategy-report/&nbsp; 
 3. Merck Manual Professional Version. Airflow, lung volumes, and flow-volume loop. Accessed January 23, 2024. https:// www.merckmanuals.com/professional/pulmonary-disorders/tests-of-pulmonary-function-pft/airflow, lung-volumes,-and-flow-volume-loop&nbsp; 
 4. Galant SP, et al. Ann Allergy Asthma Immunol. 2017;118(6):664-671.&nbsp; 
 5. Criée CP, et al. Respir Med. 2011;105(7):959-971.&nbsp; 
 6. Tseng HJ, et al. Radiographics. 2017;37(4):1037-1058.&nbsp; 
 7. Haynes JM. Respir Care. 2015;60(5):e105-e109.&nbsp; 
 8. Bui DS, et al. Ann Am Thorac Soc. 2020;17(3):302-312.&nbsp; 
 9. Stanojevic S, et al. Eur Respir J. 2022;60(1):2101499.&nbsp; 
 10.Quanjer PH, et al. Eur Respir J. 2012;40(6):1324-1343.&nbsp; 
 11.Hopp RJ, et al. Clin Rev Allergy Immunol. 2022;62(1):145-159.&nbsp; 
 12.Porojan-Suppini N, et al. Ther Clin Risk Manag. 2020;16:1139-1150.&nbsp; 
 13.Postma DS, et al. Lancet Respir Med. 2019;7(5):402-416.&nbsp; 
 14.Skylogianni E, et al. Paediatr Respir Rev. 2016;18:46-51.&nbsp; 
 15.Jerzyńska J, et al. Ann Allergy Asthma Immunol. 2015;115(4):272-276

Asthma

Latest Articles

The Role of Mucus Plugging in Asthma and Its Clinical Burden

Understanding Airway Obstruction: The Role of Mucus Plugging in Asthmatic Disease

Assessing Pediatric Lung Function