Multiple Sclerosis

MS pulse Reels - See the Bigger Picture: Why Tracking Matters

MS changes are often hard to notice day by day. This video shows how tracking over time helps you see the bigger picture and what’s really changing.

MS Pulse Reels

MS Pulse is a series of short, engaging reels covering different aspects of multiple sclerosis—from everyday challenges to practical insights. The series is designed to simplify complex topics and support better understanding, conversations, and care in MS.

Understanding 6‑Month CDP in MS: An Overview with Dr. Barry Singer

A simplified walkthrough of how 6‑month Confirmed Disability Progression (CDP) is measured in MS clinical trials. Dr. Barry Singer explains how EDSS changes are assessed, why sustained progression matters, and how this endpoint helps distinguish real, lasting disability worsening from temporary fluctuations.

Understanding Kaplan–Meier Curves in MS: An Overview with Dr. Barry Singer

Kaplan–Meier curves play a key role in visualizing how clinical events—such as confirmed disability progression—evolve over time in MS studies. In this video, Dr. Barry Singer provides a clear, simplified walkthrough of how these curves are constructed, how patient data contributes to each step, and what curve separation really tells us about treatment impact. This resource offers an accessible foundation for anyone looking to better understand KM interpretation in MS research.

Understanding PIRA in MS: An Overview with Dr. Barry Singer

Progression Independent of Relapse Activity (PIRA) represents the gradual, sustained worsening of disability that occurs even without relapses. In this video, Dr. Barry Singer explains how PIRA is defined, why it affects many patients across the MS spectrum, and how clinicians can better detect subtle changes that reflect true long-term progression.

The Role of the CNS and Periphery in MS and Disease Accumulation

Mechanism of Smoldering Disease

Smoldering Disease Burden

Smoldering Disease Overview

Smoldering Disease Detection

Disease Progression Monitoring

Btk Enzyme

Tolebrutinib Direct Effects on Myeloid Cells in PwMS

Inside MS: Explore how BTK drives immune cell activation and CNS damage

Discover the science behind Tolebrutinib: a BTK inhibitor designed to slow MS disability progression by modulating adaptive and innate immunity

Smoldering Neuroinflammation

Learning aRMMs

Why has our brain suddenly become of interest?

The reason for MS – beyond focal inflammation

The importance of deep grey matter in MS

Thalamic atrophy as a new biomarker of MS? The predictive value and how to use in clinical practice

Measuring brain atrophy. What can be done and where are we heading?

How old is your brain?

Falling chronically ill – How do I cope and move forward?

Exercise as ”medicine” in the treatment of MS

Cognitive training – A curse or a blessing?

Cognitive decline – The invisible burden of MS?

A promising biomarker in MS: Neurofilament light chain