(COPD): Disease Burden and Heterogeneity

3rd leading cause of death globally¹
6th leading cause of death in the US²

DALY, disability-adjusted life year; QALY, quality-adjusted life year.
1. World Health Organization. The top 10 causes of death. Accessed May 2, 2023. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. 2. American Lung Association. COPD Trends Brief: Mortality.
Accessed April 10, 2023. https://www.lung.org/research/trends-in-lung-disease/copd-trends-brief/copd-mortality. 3. Centers for Disease Control and Prevention. COPD. Accessed April 10, 2023. https://www.cdc.gov/dotw/copd/
Index.html#:~:text=COPD%20affects%20more%20than%2015,smoke%20and%20other%20air%20pollutants. 4. World Health Organization. Global health estimates: Leading causes of DALYs. Accessed April 17, 2023. https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/global-health-estimates-leading-causes-of-dalys. 5. Zafari Z, et al. Chest. 2021;159(4):1400-1410.

Persistent symptoms of COPD can impose substantial limitation on physical activity and contribute to worsening shortness of breath and poor HRQoL¹

Symptoms of COPD are associated with:

HRQoL, health-related quality of life.
1. Miravitlles M, Ribera A. Respir Res. 2017;18:67. 2. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Updated 2023.
Accessed March 16, 2023. https://goldcopd.org/wp-content/uploads/2022/12/GOLD-2023-ver-1.1-2Dec2022_WMV.pdf. 3. Jones PW, et al. Prim Care Respir J. 2012;21(3):329-336. 4. Kessler R, et al. Eur Respir J. 2011;37(2):264-272.
5. Jones SE, et al. J Thorac Dis. 2018;10(Suppl 12):S1390-S1399. 6. Miravitlles M, et al. Respir Res. 2014;15(1):122.

Acute exacerbations
of COPD

HRQoL, health-related quality of life.
*Patients (mean age=75.4 years) with a first severe exacerbation of COPD requiring hospitalization (N=73,106).
†Patients aged ≥35 years (N=126,013) with 252,756 index COPD-related hospitalizations.
1. Seemungal TA, et al. Am J Respir Critical Care Med. 1998;157(5 Pt 1):1418-1422. 2. Jones SE, et al. J Thorac Dis. 2018;10(Suppl 12):S1390-S1399. 3. Kessler R, et al. Chest. 2006;130 (1):133-142. 4. Suissa S, et al. Thorax. 2012;67(11):957-963. 5. Gershon AS, et al. PLoS
One. 2019;14(5):e0216741. 6. Guarascio AJ, et al. Clinicoecon Outcomes Res. 2013;5:235-245. 7. Wacker ME, et al. Int J Chron Obstruct Pulmon Dis. 2017;12:3437-3448.