Dupilumab is Efficacious Regardless of Endoscopic Phenotype: Post Hoc Analysis of the LIBERTY EoE TREET Study

ANCOVA, analysis of covariance; CI, confidence interval; DSQ, Dysphagia Symptom Questionnaire; EoE, eosinophilic esophagitis; EoEHSS, EoE Histology Scoring System; eos, eosinophils; EREFS, Endoscopic Reference Score; hpf, high-power field; LS, least squares; q2w, every 2 weeks; qw, weekly;
PEC, peak eosinophil count; PPI, proton-pump inhibitor; R, randomization; SC, subcutaneous; SD, standard deviation; SE, standard error.

Acknowledgments and funding sources: ^*Presenting on behalf of all the authors. Data originally presented at the Digestive Disease Week (DDW); San Diego, CA, USA; May 3–6, 2025. Research sponsored by Sanofi and Regeneron Pharmaceuticals Inc. ClinicalTrials.gov identifier: NCT03633617. Medical writing/editorial assistancewas provided by Sibyl Bertrand, PhD, of Adelphi Communications, Bollington, UK,and was funded by Sanofi and Regeneron Pharmaceuticals Inc., according to the Good Publication Practice guidelines. Editorial assistance for this encore poster was provided by Sowjanya M, PhD, of Sanofi.

Disclosures: Visaggi Pierfrancesco: Apogee Therapeutics, Alfasigma, Dr Falk Pharma, Phanrmaline, Malesci, Sanofi. Savarino EV: AbbVie, Agave, Alfasigma, Biogen, Bristol Myers Squibb, Celltrion, Dr. Falk, Eli Lilly, Fenix Pharma, JB Pharmaceuticals, Johnson & Johnson, Merck & Co, Nestlé, Pfizer, Reckitt Benckiser, Regeneron Pharmaceuticals Inc., Sanofi, SILA, Sofar, Takeda, Unifarco – consultancy fees; AbbVie, Agave, AGPharma, Alfasigma, CaDiGroup, Celltrion, Dr. Falk, EG Stada Group, Eli Lilly, Fenix Pharma, Galapagos, Innovamedica/Adacyte, JB Pharmaceuticals, Johnson & Johnson, Malesci, Mayoly Biohealth, Omega Pharma, Pfizer, Reckitt Benckiser, Sandoz, SILA, Sofar, Takeda, Tillotts, Unifarco – speaker fees. Peterson K: AGA, Alladapt, Allakos, AstraZeneca, Bristol Myers Squibb, Ellodi, Invea, Lucid, Nexstone, Peerview, Regeneron Pharmaceuticals Inc., Takeda, WebMD – consultancy fees; Nexeos Bio – stock and options; AGA, Allakos, Peerview, Regeneron Pharmaceuticals Inc., Takeda, WebMD – speaker fees; Allakos, Chobani – grant support. Collins MH: Alimentiv, Arena/Pfizer, AstraZeneca, Calypso Biotech, EsoCap Biotech, GSK, Receptos/Celgene/Bristol Myers Squibb, Regeneron Pharmaceuticals Inc., Shire – advisory board/consultancy fees. Xia C, Raphael BP, Radwan A: Regeneron Pharmaceuticals Inc. – employees and shareholders. Zaghloul S, Angello JT: Sanofi – employees, may hold stock and/or stock options in the company.