<h4>Average change in EDSS score in treated patients over 10 years4</h4>

<ul>
 <li>Patients with RMS have been observed to progress to nrSPMS2,3,5,6</li>
</ul>

&nbsp; 
 
 Up to 90% of disability accumulation in treated patients with RMS occurs independently of relapses1

black

<h2>A new treatment approach is urgently needed to address disability independent of relapses7</h2>

<h4>Smoldering inflammation starts early, driving disability independent of relapses throughout the disease journey, and characterizes the underlying biology of nrSPMS.7</h4>

Learn how CENRIFKI™ (tolebrutinib) can impact disability progression1

DMT=disease-modifying therapy; EDSS=Expanded Disability Status Scale; MS=multiple sclerosis; nrSPMS=non-relapsing secondary progressive multiple sclerosis; RMS=relapsing multiple sclerosis.
▼ This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side affects you may get.

1. Kappos L, Wolinsky JS, Giovannoni G, et al. Contribution of relapse-independent progression vs relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in a pooled analysis of 2 randomized clinical trials. JAMA Neurol. 2020;77(9):1132-1140. 2. Scalfari A, Traboulsee A, Oh J, et al. Smouldering-associated worsening in multiple sclerosis: an international consensus statement on definition, biology, clinical implications, and future directions. Ann Neurol. 2024;96(5):826-845. 3. Giovannoni G, Popescu V, Wuerfel J, et al. Smouldering multiple sclerosis: the 'real MS'. Ther Adv Neurol Disord. 2022;15:17562864211066751.doi:10.1177/17562864211066751 4. laffaldano P, Lucisano G, Caputo F, et al. Long-term disability trajectories in relapsing multiple sclerosis patients treated with early intensive or escalation treatment strategies. Ther Adv Neurol Disord. 2021;14:17562864211019574d. oi:10.1177/17562864211019574 5. Geladaris A, Torke S, Weber MS. Bruton's tyrosine kinase inhibitors in multiple sclerosis: pioneering the path towards treatment of progression? CNS Drugs. 2022;36(10):1019-1030. 6. Fox RJ, Bar-Or A, Traboulsee A, et al. Tolebrutinib in nonrelapsing secondary progressive multiple sclerosis. N Engl J Med. 2025;392(19):1883-1892. 7. Filippi M, Amato MP, Avolio C, et al. Towards a biological view of multiple sclerosis from early subtle to clinical progression: an expert opinion. J Neurol. 2025;272(2):179. doi:10.1007/s00415-025-12917-4. 8.Cenrifki UAE Approved SPMS 2025.

OUT-OF-TAXONOMY

Although current high-efficacy treatments successfully control relapses and lesions, many patients continue to accumulate disability independent of relapses2,3

Despite treatment, many patients with MS continue to progress independent of relapses1

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