<ul>
 <li>In MS, BTK is unregulated in a number of immune cells, including microglia and B cells, where it contributes to neuroinflammation and neurodegeneration4</li>
 <li>As a brain penetrant and bioactive molecule, CENRIFKI inhibits the BTK enzyme within microglia and B cells. The exact mechanism is not fully understood, but there is evidence to support that CENRIFKI1,2,5,6: 
 <ul>
 <li>Reaches appropriate CNS concentrations to inhibit the activation of disease-associated microglia and CNS-resident B cells—key targets involved in neurodegeneration and disability independent of relapses1,2,5,6</li>
 <li>Inhibits the activation of B cells in the periphery. B cells are involved in focal neuroinflammation and relapses1</li>
 </ul></li>
</ul>

<h2>Watch the video below to explore the MOA</h2>

OUT-OF-TAXONOMY

CENRIFKI (tolebrutinib) was designed to target the drivers of disability independent of relapses¹⁻³

BTK=Bruton’s Tyrosine Kinase; CNS=central nervous system; MOA=mechanism of action; MS=multiple sclerosis.
▼ This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side affects you may get.

1. CENRIFKI UAE SMPC 2025. 2. Hernandez-Pedro NY, Espinosa-Ramirez G, de la Cruz VP, Pineda B, Sotelo J. Initial immunopathogenesis of multiple sclerosis: innate immune response. Clin Dev Immunol. 2013;2013:413465. doi:10.1155/2013/413465 3. Scalfari A, Traboulsee A, Oh J, et al. Smoldering-associated worsening in multiple sclerosis: an international consensus statement on definition, biology, clinical implications, and future directions. Ann Neurol. 2024;96(5):826-845. 4. Filippi M, Amato MP, Avolio C, et al. Towards a biological view of multiple sclerosis from early subtle to clinical progression: an expert opinion. J Neurol. 2025;272(2):179. doi:10.1007/s00415-025-12917-4 5. Häusser-Kinzel S, Weber MS. The role of B cells and antibodies in multiple sclerosis, neuromyelitis optica, and related disorders. Front Immunol. 2019;10:201. doi:10.3389/fimmu.2019.00201 6. Giovannoni G, Popescu V, Wuerfel J, et al. Smouldering multiple sclerosis: the 'real MS.' Ther Adv Neurol Disord. 2022:15:17562864211066751. doi:10.1177/17562864211066751

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