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Mechanism of action: how QfitliaTM (fitusiran) helps restore hemostasis by lowering antithrombin for people with hemophilia1

Qfitlia works in a novel way by lowering antithrombin1,2

Antithrombin activity levels can be reliably measured.1,3

Qfitlia is an siRNA therapy that targets antithrombin and enables low treatment frequency, subcutaneous dosing, and low-volume injection.1,2

Watch this video to view the mechanism of action for Qfitlia

Explore the ATLAS-OLE trial

The ATLAS-OLE trial studied the safety and efficacy of Qfitlia using an AT-DR.1

Explore the ATLAS-OLE Trial

Discover antithrombin-based dosing

Learn how Qfitlia dosing is guided by antithrombin levels1

Learn About Dosing and Administration

MOA=mechanism of action.

References

  1. Qfitlia Prescribing Information. Genzyme Corporation. Cambridge, MA.

  2. Machin N, et al. J Blood Med. 2018;9:135-140.

  3. Advate Prescribing Information. Takeda Pharmaceuticals U.S.A., Inc. Lexington, MA.

  4. Adynovate Prescribing Information. Takeda Pharmaceutical U.S.A., Inc. Lexington, MA.

  5. Afstyla Prescribing Information. CSL Behring LLC. Kankakee, IL.

  6. ALTUVIIIO Prescribing Information. Bioverativ Therapeutics Inc. Waltham, MA.

  7. Esperoct Prescribing Information. Novo Nordisk Inc. Plainsboro, NJ.

  8. Helixate Prescribing Information. CSL Behring LLC. Kankakee, IL.

  9. Hemlibra Prescribing Information. Genentech, Inc. San Francisco, CA.

  10. Jivi Prescribing Information. Bayer HealthCare LLC. Whippany, NJ.

  11. Kogenate Prescribing Information. Bayer HealthCare LLC. Whippany, NJ.

  12. Kovaltry Prescribing Information. Bayer HealthCare LLC. Whippany, NJ.

  13. Novoeight Prescribing Information. Novo Nordisk Inc. Plainsboro, NJ.

  14. Nuwiq Prescribing Information. Octapharma USA, Inc. Paramus, NJ.

  15. Xyntha Prescribing Information. Wyeth Pharmaceuticals LLC. Philadelphia, PA.

MAT-AE-2500302-V1-April-25