The Pathophysiology of Prurigo Nodularis

CGRP, calcitonin gene-related peptide; H1/4, histamine 1/4; IL, interleukin; ILC, innate lymphoid cell; PN, prurigo nodularis; R, receptor; SP, substance P; Th, T helper cell; TSLP, thymic stromal lymphopoietin; VIP, vasoactive intestinal peptide.

1. Garcovich S, et al. Vaccines (Basel). 2021;9(3):303. 2. Shao Y, et al. Front Immunol. 2023;14:1301817. 3. Gandhi NA, et al. Nat Rev Drug Discov. 2016;15(1):35-50. 4. Yang H, et al. Int J Mol Sci. 2022;23(17):9935. 5. Nguyen JK, et al. Arch Dermatol Res. 2020;312(2):81-92. 6. Ingrasci G, et al. Exp Dermatol. 2021;30(9):1208-1217. 7. Hashimoto T, et al. J Invest Dermatol. 2021. PMID: 34023128 Review. 8. Hashimoto T, et al. Allergy. 2019;74(9):1727-1737. 9. Misery L, et al. Allergy Clin Immunol. 2023;152(1):11-23. 10. Nunomura S, et al. Cell Rep. 2023;42(1):111933. 11. Mishra SK, et al. Cell Rep. 2020;31(1):107472. 12. Kwatra S, et al. J Invest Dermatol. 2024:S0022-202X(24)01875-X. 13. Mack MR, Kim BS. Trends Immunol. 2018;39(12):980-991.14. Liang Y, et al. J Cutan Pathol. 2000;27(7):359-366. 15. Bobko S, et al. Acta Derm Venereol. 2016;96(3):404-406. 16. Agelopoulos K, et al. J Invest Dermatol. 2023;143(2):264-272.e3. 17. Feld M, et al. J Allergy Clin Immunol. 2016;138(2):500-508.e24. 18. Ständer S, et al. Presented at the 13th ISAD Congress, 31 Aug-2 Sep 2023, Gdańsk, Poland. 19. Pan D, et al. Exp Neurol. 2022;347:113909. 20. Oetjen LK, et al. Cell. 2017;171(1):217-228.e13. and suppl. 21. Mahmoud O, et al. Front Molec Neurosci. 2023;16:1272230. 22. Mack MR, et al. Front Mol Neurosci. 2023;16:1258823.

ADVENT is a medical education non-promotional program for healthcare professionals organized by Sanofi.
© 2025 Sanofi. All Rights Reserved. MAT-BH-2600276/v1/May/2026