Article
Source: Campus Sanofi
18 Dec 2025

Complex immune dysregulation impact on QoL

Author: Sanofi

Editorial Team

Complex immune dysregulation contributes to significant clinical and QoL burdens of which:

	Accelerated PLT destruction in ITP and hemolysis in wAIHA lead to thrombocytopenia and increased bleeding risk in ITP and anemia in wAIHA^1,2

	Across, ITP, wAIHA, and SCD, immune dysregulation and inflammation may influence fatigue²⁻⁴

	In SCD, chronic inflammation and a hyperactive innate immune system help sustain the vicious cycle of VOCs⁶

	Thrombo-inflammation—marked by endothelial dysfunction, complement/coagulation dysregulation, and platelet/leukocyte activation—is increasingly recognized in ITP, wAIHA, and SCD^1,5,6

	Pain has a major impact on the QoL of individuals with SCD. Both acute and chronic pain have an inflammatory component, and can lead to eventual sensitization^4,7

Abbreviations:

ITP, immune thrombocytopenia; PLT, platelet; QoL, quality of life; SCD, sickle cell disease; wAIHA, warm autoimmune hemolytic anemia; VOC, vaso-occlusive crisis.

References:

MAT-KW-2600102-V1-Mar-2026

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