<h2>Patient with Recent-ACS</h2>
Praluent®&nbsp;significantly reduced risk of MACE (primary endpoint) and is the only PCSK9i where a reduction of all-cause mortality was observed in Odyssey Outcomes trial*1,2,3,4

<h2>Patient with Diabetes &amp; ACS</h2>
Praluent®&nbsp;showed double absolute risk reduction in MACE with Diabetic patients compared to Non-diabetic patients. (Findings from a prespecified analysis of the Odyssey Outcomes trial)5

<h2>Patient with Prior CV Event &amp; Prior CABG</h2>
Praluent®&nbsp;showed greater absolute MACE reduction in ACS patients with prior CABG (Findings from a prespecified analysis of the Odyssey Outcomes trial)6

<h2>Patient with Prior CV Event &amp; Polyvascular Disease</h2>
Praluent®&nbsp;showed greater absolute MACE reduction in ACS patients with Polyvascular Disease (Findings from a prespecified analysis of the Odyssey Outcomes trial)7

Footnote:
*Study design: Odyssey Outcomes was a randomised, double-blind, placebo-controlled phase 3 study. Patients with a recent MI or unstable angina, and on high-intensity statin (40 or 80 mg atorvastatin or 20 or 40 mg rosuvastatin, or maximally tolerated dose of one of these agents) +/- other lipid-lowering therapy but not at predefined target LDL-C were enrolled. 
 †Major adverse cardiovascular events (MACE) = primary composite endpoint of CHD death, nonfatal myocardial infarction, fatal and nonfatal ischaemic stroke, or unstable angina requiring hospitalisation. 
 ‡ From prespecified subgroup analysis according to baseline LDL-C ≥100 mg/dL (N=5629). 
 §Interaction P value to assess interaction between treatment and baseline LDL-C level 
 ¥With only nominal statistical significance by hierarchical testing (HR 0.85, 95% CI 0.73, 0.98).

References

Patients at CV Risk

DYSLIPIDEMIA

CARDIOLOGY

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