<h2>Act Now</h2>
Hypothetical LDL-C lowering for patient had MI 6 months ago and on Rosuvastatin 20mg “based on scientific evidence” *

<h2>How to start Praluent®</h2>
The usual starting dose for Praluent is 75 mg administered subcutaneously once every 2 weeks.
Patients requiring larger LDL-C reduction (&gt;60%) may be started on 150 mg once every 2 weeks.1
The dose of Praluent®&nbsp;can be individualized based on patient characteristics such as baseline LDL-C level, goal of therapy, and response. Lipid levels can be assessed 4 to 8 weeks after treatment initiation or titration, and dose adjusted accordingly (up-titration or down-titration). If additional LDL-C reduction is needed in patients treated with 75 mg once every 2 weeks, the dosage may be adjusted to the maximum dosage of 150 mg once every 2 weeks.1
For patients who prefer monthly dosing, Praluent®&nbsp;offers a 300mg dosing option (administered every 4 weeks as 2 consecutive, subcutaneous 150 mg injections at 2 different injection sites, each delivered in up to 20 seconds).1

Footnote:
* Hypothetical patient only, individual responses to treatment may vary.
¶This number is based on a range of reduction spanning 13% to 20% cited in 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guidelines.
‡Target LDL-C according to 2019 ESC/EAS guidelines for the management of dyslipidaemias: &lt;70 mg/dL (&lt;1.8 mmol/L). High risk = People with markedly elevated single risk factors, in particular TC &gt;8 mmol/L (&gt;310 mg/dL), LDL-C &gt;4.9 mmol/L (&gt;190 mg/dL), or BP ≥180/110 mmHg. Patients with FH without other major risk factors. Patients with DM without target organ damage, with DM duration ≥10 years or another additional risk factor. Moderate CKD (eGFR 30-59 mL/min/1.73 m2). A calculated&nbsp;SCORE ≥5% and &lt;10% for 10-year risk of fatal CVD.
§Target LDL-C according to ESC/EAS guidelines for dyslipidaemias: &lt;55 mg/dL (&lt;1.4 mmol/L). Very high risk = People with any of the following: Documented ASCVD, either clinical or unequivocal on imaging; DM with target organ damage (microalbuminuria, retinopathy, or neuropathy), or at least 3 major risk factors, or early onset of T1DM of long duration (&gt;20 years); severe CKD (eGFR &lt;30 mL/min/1.73 m2); a calculated SCORE ≥10% for 10-year risk of fatal CVD; FH with ASCVD or with another major risk factor.

Abbreviations

References

Starting Praluent®

DYSLIPIDEMIA

CARDIOLOGY

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