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Dosing for Qfitlia™ (fitusiran) is guided by antithrombin levels1


Antithrombin activity levels can be reliably measured1,2

* Do not initiate Qfitlia dosing if antithrombin activity is <60% at baseline.1
Additional measurements can be considered if the clinical status of the patient has changed.1

Transitioning from factor replacement or BPA prophylaxis1

Patients may continue their prior factor or BPA prophylaxis for the first 7 days of Qfitlia treatment. Seven days after the initial dose of Qfitlia, discontinue factor or BPA prophylaxis.

Dosing modification guidelines for Qfitlia1

The AT-DR of Qfitlia targets antithrombin activity levels between 15% and 35%. The interactive dosing tool for Qfitlia was created to help visualize dosing modification guidelines.

Antithrombin activity levels must be measured using an FDA-cleared antithrombin activity assay1

  • Patients taking Qfitlia can have these antithrombin measurements completed at no cost through a Sanofi-Labcorp Support Program*
  • Do not initiate Qfitlia if antithrombin activity is <60% at baseline1
  • There are many laboratory tests that measure antithrombin activity levels. Antithrombin testing for patients prescribed Qfitlia must be performed using an FDA-cleared antithrombin activity assay1

How to administer Qfitlia—a video for patients

Watch this video to learn how patients can self-inject Qfitlia.

Learn about the dose modification tool for Qfitlia

Explore the Qfitlia dose adjustment tool.

Understand breakthrough bleed guidance

Learn the guidelines for using on-demand factor replacement or BPA treatments to manage breakthrough bleeds while on Qfitlia.

AT=antithrombin; AT-DR=antithrombin-based dosing regimen; BPA=bypassing agent; FDA=US Food and Drug Administration; M1=Month 1; M2=Month 2; M3=Month 3; M4=Month 4; M5=Month 5; M6=Month 6.

References

  1. Qfitlia Prescribing Information. Genzyme Corporation. Cambridge, MA.

  2. Data on file, October 2024.

  3. Data on file CSR. SAR439774-LTE15174 - fitusiran. November 2023.

MAT-AE-2500302-V1-April-25