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Background: RSV infections impose a substantial burden that goes beyond their clinical effects, significantly impacting healthcare resource consumption, existing data indicates a substantial healthcare and economic burden in Saudi Arabia, with early diagnosis costs estimated at $16,692 per patient.
Objective: to assess healthcare utilization and associated costs of RSV infection among children under 5 years of age
Methods: Retrospective cohort study of children aged ≤5 years with documented RSV testing• Study period: Jan 1, 2018 – Dec 31, 2023• Conducted across MNGHA facilities in KSA• Five hospitals (Riyadh, Jeddah, Al-Ahsa, Al-Madinah, Dammam)• 71 affiliated PHCs• Variables assessed: age, hospital & ICU admissions, LOS• Direct healthcare costs estimated from ICU, ward, ED/OPD, diagnostic and treatment-related expenses

Number of laboratory-confirmed RSV cases across different age groups

  • 34,957 children were analyzed, including 7,371 RSV-positive and 27,586 RSV-negative cases
  • Median age wfor RSV-negative children
  • RSV-positive cases had significantly higher hospital admission rates (63.2% vs. 26.2%) as 10.0 months for RSV-positive children vs 12.3 months
  • The majority of RSV-positive children were previously healthy (95.3%) ,A small proportion had underlying comorbidities (4.7%)
  • Infants aged <12 months contributed to a substantial proportion of laboratory-confirmed RSV cases

 Proportional distribution of laboratory-confirmed RSV cases across the study years
 

  • infants <12 months contributed to a substantial proportion of cases, with peak incidence in 2022

 Proportion of children with laboratory-confirmed RSV infection by associated comorbidities

  • The majority of RSV-positive children were previously healthy (95.3%)
  • A small proportion had one or more comorbidities (4.7%)
  • Reported comorbidities included congenital heart disease, congenital anomalies, and chronic illnesses

Table 1. Estimated direct medical cost (SAR) distributed by year of diagnosis

VariablesY2018 (n=1037)Y2019 (n=1248)Y2020 (n=699)Y2021 (n=794)Y2022 (n=2590)Y2023 (n=1003)
ICU admission cost

171,405

122,850

115,128

957,528

1,507,838

565,208

Ward admission cost

357,675502,775186,2502,730,1638,309,6001,924,950
Emergency Department/ Outpatient visit cost414,800499,200279,600317,6001,036,000401,200
Diagnostic and Treatment cost241,300330,600149,150684,0002,393,050624,150
Overall direct medical cost1,185,1801,455,425730,1284,689,29113,246,4883,515,508
Average direct medical cost per case1142.891166.211044.535905.915114.473504.99

Table 1 – Key Findings (By Year)

  • Overall direct medical costs increased over time, peaking in 2022 at 13.25 million SAR.
  • Costs were markedly higher in 2021 (4.69 million SAR) and declined in 2023 (3.52 million SAR).

Table 2. Estimated direct medical cost (SAR) distributed by age at diagnosis
 

VariablesY2018 (n=1037)Y2019 (n=1248)Y2020 (n=699)Y2021 (n=794)Y2022 (n=2590)Y2023 (n=1003)
ICU admission cost

514,800

1,105,650

234,000

409,617

587,087

117,000

Ward admission cost

787,0502,280,1631,637,7001,932,0001,494,588720,300
Emergency Department/ Outpatient visit cost149,200490,400440,000542,000384,000218,800
Diagnostic and Treatment cost225,150732,450618,450781,850575,700329,650
Overall direct medical cost1,676,2004,608,6632,930,1503,665,4673,041,3751,385,750
Average direct medical cost per case4493.833759.112663.772705.143168.102533.36

Table 2 – Key Findings (By Age)

  • The highest direct medical cost was observed among infants aged 1–2 months (4.61 million SAR).
  • High costs were also reported in infants aged 6–11 months (3.67 million SAR) and 3–5 months (2.93 million SAR).
  • Infants aged 0–12 months incurred higher costs compared with older age groups.

MAT-BH-2500613-V1.0-February 2026