- Article
- Source: Campus Sanofi
- 21 Nov 2025
Healthcare Utilization and Economic Burden of RSV Infections Among Children Under 5 Years in Saudi Arabia: A MNGHA Facilities Analysis

| Background: RSV infections impose a substantial burden that goes beyond their clinical effects, significantly impacting healthcare resource consumption, existing data indicates a substantial healthcare and economic burden in Saudi Arabia, with early diagnosis costs estimated at $16,692 per patient. |
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Number of laboratory-confirmed RSV cases across different age groups
- 34,957 children were analyzed, including 7,371 RSV-positive and 27,586 RSV-negative cases
- Median age wfor RSV-negative children
- RSV-positive cases had significantly higher hospital admission rates (63.2% vs. 26.2%) as 10.0 months for RSV-positive children vs 12.3 months
- The majority of RSV-positive children were previously healthy (95.3%) ,A small proportion had underlying comorbidities (4.7%)
- Infants aged <12 months contributed to a substantial proportion of laboratory-confirmed RSV cases

Proportional distribution of laboratory-confirmed RSV cases across the study years

- infants <12 months contributed to a substantial proportion of cases, with peak incidence in 2022
Proportion of children with laboratory-confirmed RSV infection by associated comorbidities

- The majority of RSV-positive children were previously healthy (95.3%)
- A small proportion had one or more comorbidities (4.7%)
- Reported comorbidities included congenital heart disease, congenital anomalies, and chronic illnesses
Table 1. Estimated direct medical cost (SAR) distributed by year of diagnosis
| Variables | Y2018 (n=1037) | Y2019 (n=1248) | Y2020 (n=699) | Y2021 (n=794) | Y2022 (n=2590) | Y2023 (n=1003) |
|---|---|---|---|---|---|---|
| ICU admission cost |
171,405 |
122,850 |
115,128 |
957,528 |
1,507,838 |
565,208 |
|
Ward admission cost | 357,675 | 502,775 | 186,250 | 2,730,163 | 8,309,600 | 1,924,950 |
| Emergency Department/ Outpatient visit cost | 414,800 | 499,200 | 279,600 | 317,600 | 1,036,000 | 401,200 |
| Diagnostic and Treatment cost | 241,300 | 330,600 | 149,150 | 684,000 | 2,393,050 | 624,150 |
| Overall direct medical cost | 1,185,180 | 1,455,425 | 730,128 | 4,689,291 | 13,246,488 | 3,515,508 |
| Average direct medical cost per case | 1142.89 | 1166.21 | 1044.53 | 5905.91 | 5114.47 | 3504.99 |
Table 1 – Key Findings (By Year)
- Overall direct medical costs increased over time, peaking in 2022 at 13.25 million SAR.
- Costs were markedly higher in 2021 (4.69 million SAR) and declined in 2023 (3.52 million SAR).
Table 2. Estimated direct medical cost (SAR) distributed by age at diagnosis
| Variables | Y2018 (n=1037) | Y2019 (n=1248) | Y2020 (n=699) | Y2021 (n=794) | Y2022 (n=2590) | Y2023 (n=1003) |
|---|---|---|---|---|---|---|
| ICU admission cost |
514,800 |
1,105,650 |
234,000 |
409,617 |
587,087 |
117,000 |
|
Ward admission cost | 787,050 | 2,280,163 | 1,637,700 | 1,932,000 | 1,494,588 | 720,300 |
| Emergency Department/ Outpatient visit cost | 149,200 | 490,400 | 440,000 | 542,000 | 384,000 | 218,800 |
| Diagnostic and Treatment cost | 225,150 | 732,450 | 618,450 | 781,850 | 575,700 | 329,650 |
| Overall direct medical cost | 1,676,200 | 4,608,663 | 2,930,150 | 3,665,467 | 3,041,375 | 1,385,750 |
| Average direct medical cost per case | 4493.83 | 3759.11 | 2663.77 | 2705.14 | 3168.10 | 2533.36 |
Table 2 – Key Findings (By Age)
- The highest direct medical cost was observed among infants aged 1–2 months (4.61 million SAR).
- High costs were also reported in infants aged 6–11 months (3.67 million SAR) and 3–5 months (2.93 million SAR).
- Infants aged 0–12 months incurred higher costs compared with older age groups.
- Farahat F, Alshanrani M, Alsager K, Alzunitan M, Alsacedi A, Alahmadi M, et al. Healthcare utilization and economic burden of RSV infections among children under 5 years in Saudi Arabia: A MNGHA facilities analysis. Presented at: KSA ID Week; 2025; Saudi Arabia.
- Du Y, Yan R, Wu X, et al. Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 study. Int J Infect Dis. 2023;135:70-76. doi:10.1016/j.ijid.2023.08.008.
- Assiri AM, Alsulami FSF, Amer SA, et al. The economic burden of viral severe acute respiratory infections in the Kingdom of Saudi Arabia: A nationwide cost-of-illness study. J Infect Dis Reg. 2024;10:80-86. doi:10.1016/j.jireg.2023.11.016.
MAT-BH-2500613-V1.0-February 2026