ASTHMA

RESPIRATORY

How does Dupixent improve Asthma control and quality of live for Pediatric Patients?

&nbsp;KOL Expert on Asthma Control and Quality of Life for Pediatric.

Fractional exhaled nitric oxide (Feno)

<h3>FENO: Simple non invasive direct measure of local airway inflammation in asthma which is a Predictor of:</h3>
<ul>
 <li>Loss of asthma control</li>
 <li>Risk of exacerbation</li>
 <li>Lung function decline</li>
</ul>

References

OTHER-DIABETES-TOPICS

DIABETES

Real-world evidence of treatment intensification in people with T2D inadequately controlled on GLP-1 RAs

Insights from Prof. Timothy Baily on new Real-world evidence in deliver G study and the implications of adding Toujeo®&nbsp;to people with T2D inadequately controlled on GLP-RAs.

Asthma Clinical Remission: The Benchmarks for Eliminating Airway Inflammation and Symptoms

What is the the Clinical Remission:&nbsp;Clinical remission: ≥12 months of all of the following, whether on or off treatment.
<ul>
 <li>Consistent absence of significant asthma symptoms based on validated instruments</li>
 <li>Optimized and stabilized lung function.</li>
 <li>Patients and provider agreement of disease remission.</li>
 <li>No exacerbations required OCS and/or hospitalization</li>
</ul>

Consider Dupixent for Asthmatic patients with OCS use

Dupixent proved its efficacy to lower the OCS use &amp; reduce exacerbations along with improving Lung function.

Acquired

Thrombotic

Thrombocytopenic

Purpura

Acquired or immune-mediated thrombotic thrombocytopenic purpura (aTTP) is a rare blood disorder that develops when the immune system stops ADAMTS13 from working properly. This syndrome is characterized by anemia caused by damage to red blood cells accompanied by a low platelet count, neurologic symptoms, and renal disease.1
<table border="1" cellpadding="1" cellspacing="1" style="height: 120px; width: 700px;">
 <tbody>
 <tr>
 <td>aTTP share many similarities with other blood diseases, whose treatment algorithms are different from aTTP. Thus, accurate diagnosis is an essential step to accurately prescribe an effective treatment. To do so, ADAMTS13 activity testing should be done.1</td>
 </tr>
 </tbody>
</table>
<table border="1" cellpadding="1" cellspacing="1" style="width:700px;">
 <tbody>
 <tr>
 <td style="text-align: center; background-color: rgb(68, 11, 18);">Your role is crucial to the diagnosis and speed of appropriate treatment for aTTP</td>
 </tr>
 </tbody>
</table>

ADAMTS13 Activity testing will help confirm or exclude your patient’s TTP disease diagnosis. In addition, the test results may assist clinical decision making in the treatment of aTTP.2

The management of exacerbations and disease relapse is an important aspect of treatment and follow-up of patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP), also known as acquired TTP. Severe ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) deficiency during clinical remission is associated with risk of relapse and may guide prophylactic immunemodulatory therapy.

black

Patients with TTP in remission should have regular ADAMTS13 activity measurements during follow- up. Although not based on a formal review of published evidence, it is suggested that ADAMTS13 levels should be assessed monthly for the first 3 months, every 3 months through the first year, and every 6–12 months thereafter.1 A decline in ADAMTS13 activity might warrant more frequent measurements, as persistently low levels may increase the risk for relapse.4,5

A blood sample for ADAMTS13 testing (ADAMTS13 activity and inhibitors or anti-ADAMTS13 IgG) should be obtained prior to initiation of therapeutic plasma exchange (TPE) or any blood product in a patient with clinical suspicion of TTP.4

SANOFI, Level 3, One JLT, Jumeirah Lake Towers (JLT), DMCC, PO Box 53899, Dubai, UAE Tel.:&nbsp;<a href="tel:+971 4 550 3600" target="_blank">+971 4 550 3600</a>&nbsp;| Fax: +971 4 5521050 For further medical information, please contact: For UAE ✆ 800 MEDICAL Toll-Free Number. For all Gulf countries ✆&nbsp;<a href="tel:+971 45 50 38 63" target="_blank">+971 45 50 38 63</a>&nbsp;or email: medical-information.gulf@sanofi.com. To report an adverse event or drug reaction, please contact us on: 24/ 7 Pharmacovigilance reporting number:&nbsp;<a href="tel:+971 561747001" target="_blank">+971 561747001</a>&nbsp;e-mail:&nbsp;<a href="mailto:gulf.pharmacovigilance@sanofi.com" target="_blank">gulf.pharmacovigilance@sanofi.com</a>&nbsp;SANOFI, SAUDI ARABIA , TAHLIA STREET, NOJOUD CENTER, GATE C, 1ST FLOOR, P.O. BOX 9874, JEDDAH 21423, SAUDI ARABIA For Medical Information: Please contact:<a href="tel:+966126693318" target="_blank">+966126693318</a>&nbsp;Email:&nbsp;<a href="mailto:ksa.medicalinformation@sanofi.com" target="_blank">ksa.medicalinformation@sanofi.com</a>&nbsp;Website: www.sanofi.com.sa For Pharmacovigilance, Please contact:&nbsp;<a href="tel:+966-54-428-4797" target="_blank">+966-54-428-4797</a>,&nbsp;<a href="mailto:ksa_pharmacovigilance@sanofi.com" target="_blank">ksa_pharmacovigilance@sanofi.com</a>&nbsp;To report any product technical complaints, kindly contact quality.greatergulf@sanofi.com. To report any side effect(s),Saudi Arabia: The National Pharmacovigilance Centre (NPC): SFDA Call Center: 19999 E-mail:&nbsp;<a href="mailto:npc.drug@sfda.gov.sa" target="_blank">npc.drug@sfda.gov.sa</a>&nbsp;Website:<a href="http://https//ade.sfda.gov.sa/" target="_blank">https://ade.sfda.gov.sa/</a>

ACQUIRED-THROMBOTIC-THROMBOCYTOPENIA-PURPURA-ATTP

RARE-BLOOD-DISORDERS

aTTP is a Medical Emergency With Long Term Consequences

Airway Hyperresponsiveness
in Asthma

<h2 style="text-align: center;">Proposed Framework for Remission1-7</h2>

<table border="1" cellpadding="1" cellspacing="1" style="width:500px;">
 <tbody>
 <tr>
 <td style="background-color: rgb(21, 144, 165);">
 <h3 style="text-align: center;">Remission: A state or period with low to no disease activity that can be spontaneous or as a result of therapy6</h3></td>
 </tr>
 </tbody>
</table>

<h3 style="text-align: center;">Several Countries Have Recommended Clinical Remission Definitions1-5</h3>

*A broad consensus definition is being developed with over 120 experts and is expected in the GEMA 5.4 update.
†The US workgroup determined that symptom and lung function criteria must be met on all occasions measured in the previous 12-month period with a minimum of two measurements during the year.

<table border="1" cellpadding="1" cellspacing="1" style="width:500px;">
 <tbody>
 <tr>
 <td style="background-color: rgb(21, 144, 165);">
 <h3 style="text-align: center;">The definition of on-treatment remission in asthma has not yet been established and further consensus among experts, guidelines, and societies is warranted.6</h3></td>
 </tr>
 </tbody>
</table>
This tool showcases the evolving evidence around asthma remission as of February 2024 and is intended for educational purposes only.
ACQ, Asthma Control Questionnaire; ACT, Asthma Control Test; AirQ, Asthma Impairment and Risk Questionnaire; FEV1, forced expiratory volume in 1 second; ICS, inhaled corticosteroids; OCS, oral corticosteroids.

<h2 style="text-align: center;">EVOLUTION OF ON-TREATMENT REMISSION IN ASTHMA</h2>
<h3 style="text-align: center;">How Can Therapeutic Intervention Get Us to On-Treatment Clinical Remission?6-10</h3>

<h3 style="text-align: center;">Over 70-Years of On-Treatment Clinical Remission in Asthma</h3>

<table border="1" cellpadding="1" cellspacing="1" style="width:500px;">
 <tbody>
 <tr>
 <td style="background-color: rgb(21, 144, 165);">
 <h3 style="text-align: center;">Remission may be achieved on or off treatment. Different definitions of remission have been proposed and implemented in various studies. Given this evolving framework for remission, further studies may provide a pathway to inform our understanding of disease modification in severe asthma.6</h3></td>
 </tr>
 </tbody>
</table>
This tool showcases the evolving evidence around asthma remission as of February 2024 and is intended for educational purposes only.
ICS, inhaled corticosteroids; LABA, long-acting beta agonist; SABA, short-acting beta agonist; SCS, systemic corticosteroids.

<h2 style="text-align: center;">REDUCING EXACERBATIONS IS A FUNDAMENTAL CRITERION OF ASTHMA REMISSION1-7</h2>

*Adapted from GINA and ERS/ATS.&nbsp;†Severe exacerbation was defined as worsening asthma requiring at least 3 days of treatment with systemic corticosteroids, or a hospitalization due to asthma. ATS, American Thoracic Society; BD, bronchodilator; ERS, European Respiratory Society; FEV1, forced expiratory volume in 1 second; GINA, Global Initiative for Asthma.

<h2 style="text-align: center;">ZERO OCS USE IS REQUIRED FOR A STATE OF ASTHMA REMISSION1-7</h2>

*Adapted from GINA and ERS/ATS.&nbsp;†P&lt;0.001.20 
 AE, adverse event; ATS, American Thoracic Society; ERS, European Respiratory Society; GI, gastrointestinal; GINA, Global Initiative for Asthma; OCS, oral corticosteroids.

<h2 style="text-align: center;">ACHIEVING LUNG FUNCTION STABILIZATION OR IMPROVEMENT IS A KEY COMPONENT OF ASTHMA REMISSION1-7</h2>

*Adapted from GINA and ERS/ATS.&nbsp;†n=1865; Cox proportional hazard model analysis adjusted for age at index date, smoking status, body mass index, gender, rhinitis, chronic sinusitis, nasal polyps, atopic dermatitis, diabetes, anaphylaxis, ischemic heart disease, heart failure, food allergy, anxiety, depression, and psoriasis.8 ‡n=1075; relative risk of death from asthma during 25 years of follow-up.9 ATS, American Thoracic Society; BD, bronchodilator; CI, confidence interval; ERS, European Respiratory Society; FEV1, forced expiratory volume in 1 second; FEV1pp, FEV1&nbsp;percent predicted; GINA, Global Initiative for Asthma; HR, hazard ratio.

<h2 style="text-align: center;">LONG-TERM SYMPTOM CONTROL IS AN IMPORTANT PATIENT-REPORTED COMPONENT OF ASTHMA REMISSION1-7</h2>

*Adapted from GINA and ERS/ATS. 
 ACQ, Asthma Control Questionnaire; ACT, Asthma Control Test; ATS, American Thoracic Society; BD, bronchodilator; ERS, European Respiratory Society; FEV1, forced expiratory flow in 1 second; GINA, Global Initiative for Asthma.

ON-TREATMENT ASTHMA REMISSION: MOVING BEYOND CONTROL

The ISTH TTP Guidelines are the first evidence-based, international guidelines on the diagnosis, treatment, and management of TTP. The guidelines emphasize the importance of diagnosis through clinical assessment or risk assessment tools, such as the French or PLASMIC score. Clinical assessment can help predict the likelihood of severe ADAMTS13 deficiency in a patient with suspected TTP and guide treatment decisions.1
Inform your approach to thrombotic thrombocytopenic purpura (TTP) treatment by understanding key clinical considerations and therapeutic options.

The International Society on Thrombosis and Haemostasis (ISTH) TTP Guideline

TTP is a life-threatening thrombotic microangiopathy (TMA) that requires quick diagnosis and urgent treatment. 1,2

Resources

TTP is a life-threatening thrombotic microangiopathy (TMA) that requires quick diagnosis and urgent treatment. 1,2

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Atopic dermatitis, a type of eczema, may be affecting your Patient's life in more ways than you know.

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