Latest Articles

Understanding Type 2 and Non-Type 2 Inflammation in Atopic Dermatitis

Atopic dermatitis (AD) is a heterogenous disease defined by contributions from multiple distinct inflammatory pathways.¹ Although type 2 inflammation‘s role in AD pathogenesis is well-characterized, other non-type 2 T cell-mediated pathways also play a role in AD chronicity.^1,2 For healthcare professionals seeking to understand the diversity of immune signatures in their AD patients, looking beyond Th2 cytokines is essential.¹

Understanding the Burden of Moderate-to-Severe Atopic Dermatitis

Atopic dermatitis (AD) is a chronic, immune-mediated inflammatory disease that often begins in early infancy and persists into adulthood.^1-3 While symptoms such as the intense itch that disrupts the lives of patients are well known, AD also imposes a profound chronic ‘hidden burden’ that extends far beyond visible skin lesions, significantly impairing patients' mental health, relationships, and daily productivity.^1-11 This burden can be compounded by the treatment regimens themselves, which can be time-consuming, economically straining, and limited by low patient satisfaction and patient phobias of treatments and their side effects.^12-14

Mucopolysaccharidosis type I (MPS I) clinical features and symptom presentation

Types of Infusions for Treatment of Hemophilia

Hemophilia is an inherited bleeding disorder caused by a deficiency of either clotting factor VIII (hemophilia A) or IX (hemophilia B), leading to impaired blood clotting and an increased risk of prolonged or spontaneous bleeding. Clotting factor therapy, which involves intravenous administration of factor VIII or IX, restores the clotting and remains a cornerstone of hemophilia management.^1,2 While other treatments are available, this article focuses specifically on clotting factor replacement delivered through intravenous infusion.

Factor VIII Deficiency and Hemophilia A: Understanding High and Low Factor Activity Levels

Hemophilia A is a bleeding disorder caused by Factor VIII (FVIII) deficiency, with severity linked to FVIII activity levels. This article explores FVIII biology, defines activity ranges, and reviews current approaches to replacement therapy.

Learn how to recognize and manage Gaucher disease type 3

Factor VIII Activity Assays - A Guide to PK Testing

Pharmacokinetic (PK) testing with accurate Factor VIII assays may help personalize hemophilia A treatment.^1,2 This article reviews one-stage and chromogenic methods and their clinical use.

How ASMD Can Impact Quality of Life and Average Life Expectancy​

Fabry Disease Treatment and Management