Skip to main content
SYNVISC® (hylan G-F 20) Family logo

Medicaid Insurance Reimbursement for SYNVISC® (hylan G-F 20) and SYNVISC-ONE® (hylan G-F 20)


SYNVISC and SYNVISC-ONE Medicaid coverage

Coverage, access, and reimbursement will vary by state as well as by the patient's Medicaid eligibility status, so it is important to verify a patient's Medicaid program benefits for SYNVISC and SYNVISC-ONE.

In addition, you should confirm whether Medicaid patients have other forms of insurance. Medicaid is the payer of last resort, so in cases where patients have Medicare or other types of supplemental commercial insurance, Medicaid always pays secondary or tertiary to these payers.

State Medicaid programs cover drugs under the medical and/or pharmacy benefit(s). Physician-administered products, like SYNVISC and SYNVISC-ONE, generally are covered under the medical benefit.

Some states, however, may manage drug coverage and reimbursement through the pharmacy benefit. In these cases, patients obtain the drug at a pharmacy and bring it to the physician's office for administration. In addition to confirming a patient's eligibility and benefits under Medicaid, it is important to confirm under what guidelines SYNVISC and SYNVISC-ONE should be obtained. For example, some states may place quantity restrictions on the number of prescriptions filled per month, some may require that patients obtain the product through specific retail pharmacies, and others may require PA.

SYNVISC and SYNVISC-ONE Medicaid reimbursement

States mandate their individual drug reimbursement methods. While methods vary, state Medicaid agencies usually pay for products administered in the office and hospital outpatient settings based on AWP or ASP. Medicaid payment policies for SYNVISC and SYNVISC-ONE administration and associated office visits typically are similar to those under Medicare, with reimbursement structured according to a physician fee schedule.

Find Prior Authorization Form

Providers retain sole responsibility for determining reimbursement and insurance issues related to their patients and for ensuring the accuracy of their submission claims. Sanofi cannot be responsible for failure of a provider to obtain reimbursement.

Yellow file folder icon

Specialty Pharmacy Forms

Find prior authorization and other carrier-specific forms required for ordering.

Blue rounded square with a white check mark inside a folder icon.

Did you know you can order SYNVISC/ SYNVISC-ONE at SanofiShoppe.com?

Important Safety Information

SYNVISC and SYNVISC-ONE are contraindicated in patients with known hypersensitivity to hyaluronan products or patients with infections in or around the target knee. Hypersensitivity reactions including anaphylactic reaction, anaphylactoid reaction, anaphylactic shock and angioedema have been reported for both SYNVISC and SYNVISC-ONE. 

Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation because hyaluronan can precipitate in their presence. Do not inject SYNVISC or SYNVISC-ONE extra-articularly, into the synovial tissues, into the fat pad or joint capsule, or intravascularly. Some cases of skin necrosis have been reported after intra-articular use of hyaluronic acid. Patients should be instructed to contact their treating physician if signs of skin disorder (such as change of color or open sores) appear. SYNVISC and SYNVISC-ONE are only intended for use by a healthcare professional adequately trained to administer intra-articular injections, according to standard medical practices.

The safety and efficacy of SYNVISC or SYNVISC-ONE in locations other than the knee, or for conditions other than osteoarthritis, or in combination with other intra-articular injectables, or in severely inflamed knee joints have not been established. Use caution when injecting SYNVISC or SYNVISC-ONE in patients allergic to avian proteins, feathers, or egg products; who have evidence of lymphatic or venous stasis in the leg to be treated; or who have severe inflammation in the knee to be treated. Remove any synovial fluid or effusion before injecting SYNVISC or SYNVISC-ONE. Strict adherence to aseptic technique must be followed to avoid joint infection. The safety and effectiveness of SYNVISC and SYNVISC-ONE have not been established in children (≤21 years old) or in pregnant or lactating women. Patients should be advised to avoid strenuous or prolonged weight-bearing activities for approximately 48 hours after treatment.

Indication

SYNVISC® (hylan G-F 20) and SYNVISC-ONE® (hylan G-F 20) are indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information

Indication

SYNVISC, SYNVISC-ONE, Sanofi Patient Connection and Sanofi are registered trademarks of Sanofi or an affiliate. All other trademarks mentioned above are the property of their respective owners. MAT-US-2005855-v4.0-01/2026