- Artikel
- Bron: Campus Sanofi
- 9 apr 2025
Underneath the skin

Introduction
- How do uncontrolled AD and PN uniquely impact patient lives?
- What are the specific challenges faced by individuals with uncontrolled AD and PN?
- Why is recognizing the high burden of uncontrolled AD and PN critical for healthcare professionals?
The silent struggles of living with uncontrolled AD and PN
Living with uncontrolled AD or PN extends far beyond physical discomfort. These conditions exert a substantial psychological toll, with patients grappling with heightened anxiety, depression, and social stigma1,2. In AD, there is 1.7 times higher odds of any depression compared to healthy individuals, and almost a 2 times higher odd of suicidal ideation compared to healthy individuals3.
Disruptions to daily life are also profound, with severe sleep disturbances common among patients, significantly degrading their quality of life and illustrating the diseases far reaching effects4,5.
The unseen impact on personal and professional life of uncontrolled AD and PN
The ramifications of uncontrolled AD and PN permeate every aspect of patients lives, from personal relationships to professional endeavors1,6. Patients with severe AD, on average, miss significantly more work days annually compared to those with moderate and mild AD. Specifically, adults with severe AD miss an average of 45.4 days, those with moderate AD miss 24.7 days of work/study each year7. The relentless itch experienced by PN patients, often more severe than in other skin diseases8 , exacerbates these challenges. The struggle extends to personal spheres, where maintaining normal social interactions and personal relationships becomes a herculean task due to the visible and distressing symptoms9.
Breaking the cycle: Addressing uncontrolled AD and PN
In response to the multifaceted challenges of uncontrolled AD and PN, there's a growing emphasis on developing more effective treatment strategies1,7,10. This involves a holistic approach, considering both the physical and psychological aspects of these conditions1,11. Prompt escalation to targeted therapies is becoming increasingly recognized as crucial in managing uncontrolled patients1,7,10. Healthcare professionals are encouraged to adopt a comprehensive and empathetic treatment approach, focusing on the broader impact of these conditions on patients lives12.
Conclusion
Uncontrolled AD and PN are not merely skin conditions; they profoundly impact patients lives in multiple dimensions. It is imperative for healthcare professionals to understand the extensive suffering endured by these patients. Progress in understanding and treating these conditions is ongoing, with an emphasis on empathy and comprehensive care approaches6,13.
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Simpson EL, et al. J Am Acad Dermatol. 2016;74:491-498
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de Bruin-Weller M, et al. J Dermatol Treat. 2021;32(2):164-173
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Bruin-Weller M, et al. SID. May 8-11, 2019; Chicago, IL. Oral presentation
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Kwon CD et al. Medicines (Basel). 2019;6(4)97
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Zeidler C et al. Dermatol Clin. 2018;36:189-197
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Aggarwal Pet al. Clin Exp Dermatol. 2021;46(7):1277-1284
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Todberg T et al. Acta Derm Venereal. 2020;100(8):adv001197
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Huang AH et al. Journal of Investigative Dermatology. 2020;140:480-483
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Steinke Set al. J Am Acad Dermatol. 2018;79(3):457-463 (Suppl. 463.e3)
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MAT-BE-2500419 1.0 03/25