TYPE-2-DIABETES

TYPE-1-DIABETES

DIABETES

FOR COMPLETE PROGRAM VISIT THE CONGRESS WEBSITE

Overcoming Therapeutic Inertia - Leveraging the Diabetes Care Interprofessional Team1

<a href="#the-therapeutic-education-corner">READ MORE</a>

&nbsp;

SURMOUNT-2 Trial Results and Potential Role of Tirzepatide in Treating Obesity in Type 2 Diabetes3

<a href="#the-incretin-corner">READ MORE</a>

The Jekyll and Hyde of Inflammatory Signals in Islets

<a href="#the-basic-science-corner">READ MORE</a>

Updates in ADA&#39;s Standards of Care in Diabetes - 20236

<a href="#the-ada-corner">READ MORE</a>

A 360-Degree Examination of Type 1 Diabetes: From Patient Identification to Treatment and Prevention

<a href="#the-new-normal-corner">READ MORE</a>

<h2>The Therapeutic Education Corner</h2>
<h4>Overcoming Therapeutic Inertia—Leveraging the Diabetes Care Interprofessional Team</h4>
This symposium was chaired by Nuha Ali El Sayed and featured a presentation by Kevin Pantalone in which he discussed the definition, key contributors, challenges and best practices to overcome TI in T2D. He highlighted that people with T2D (PwT2D) must follow “Treat To Target” approach instead of historical “Treat To Failure” approach for effective diabetes management. Further, he emphasized the importance of leveraging the diabetes care team to identify as many as touchpoints with our patients to overcome TI in PwT2D.
During the presentation, the panelists (Kevin Pantalone, Sandra Leal and Lucia Novak) discussed diverse case studies and best practices to tackle TI with the use of technology (telehealth, continuous glucose monitoring, coaching programs etc.), dedicated endocrine pharmacists and schedule follow-up visits of patients with clinicians to achieve recommended glycemic targets.

Fig. 1:&nbsp;Word cloud representation of feedback from the 2018 therapeutic inertia summit. Participants were asked to list the top three words that describe potential solutions to therapeutic inertia. The size of the words indicates the relative frequency with which they were mentioned2.

<h2>The Incretin Corner</h2>
<h4>SURMOUNT-2 Trial Results and Potential Role of Tirzepatide in Treating Obesity in Type 2 Diabetes</h4>
The SURMOUNT-2 trial was a 72-week, randomized, multicenter, double-blind study, designed to assess the safety and efficacy of Tirzepatide 10 mg and 15 mg, and placebo for chronic weight management in PwT2D with obesity.
In the SURMOUNT-2 study, both Tirzepatide 10 mg and 15 mg doses demonstrated superiority and clinically meaningful body weight reduction versus placebo (primary endpoint). Moreover, the tolerability and safety profile of Tirzepatide in PwT2D with obesity was consistent with the SURPASS studies results and that of other incretin-based therapies for obesity. The most frequent AE reported were GI-related (mild-moderate) and no severe hypoglycemia was reported.
However, some critical outstanding questions from the SURMOUNT-2 study include durability beyond 1.5 years, cardiac and renal outcomes, early use in younger patients, RWE data and healthcare savings with Tirzepatide.
The results of this study are now published in The Lancet journal.

Fig.2:&nbsp;Effect of once weekly&nbsp;<a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/tirzepatide" title="Learn more about tirzepatide from ScienceDirect's AI-generated Topic Pages">tirzepatide</a>, compared with&nbsp;<a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/placebo" title="Learn more about placebo from ScienceDirect's AI-generated Topic Pages">placebo</a>, on HbA1c and bodyweight. (A) HbA1c&nbsp;values over time from MMRM analysis for the efficacy estimand and week 72 estimates from&nbsp;<a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/analysis-of-covariance" title="Learn more about ANCOVA from ScienceDirect's AI-generated Topic Pages">ANCOVA</a>&nbsp;for the treatment-regimen estimand. (B) Percent change in bodyweight over time from baseline to 72 weeks, derived from a mixed-model for repeated-measures analysis for the efficacy estimand; week 72 estimates for the treatment-regimen estimand are also shown.

<h2>The Basic Science Corner</h2>
<h4>The Jekyll and Hyde of Inflammatory Signals in Islets</h4>
On the last day of the congress, Daniël van Raalte presented the role of gut microbiota in diabetes. Evidence shows that low-grade beta-cell inflammation has been identified in type 2 diabetes (T2D). On the other hand, “Gut dysbiosis” has been proposed in people with T2D. Therefore, microbiota may participate to the induction of islet cell inflammation and dysfunction. However, causality has yet to be proven.4
Regarding T1D, the role of microbiota is clearer in autoimmune development and fecal transplant is being proposed for potential therapy for T1D; clinical trials in Vancouver, Canada are underway.5

Fig 3.:&nbsp;Study schematic showing which analyses were performed (left). Left graph: Change in fasting C peptide over time. Arrows indicate when FMT (allogenic: blue and autologous: pink with width of colour band indicating SD) was performed. Ribbons indicate CIs. Significance was calculated using LMM, *** p=0.00019. Right graph: Change in C peptide AUC over time. Significance was calculated using LMM, **** p=0.000067. AUC, area under the curve; FMT, faecal microbiota transplantation; LMM, linear mixed model; T1D, type 1 diabetes.

<h2>The ADA Corner</h2>
<h4>Updates in ADA’s Standards of Care in Diabetes—2023</h4>
This symposium was chaired by Dr. Nuha Ali El Sayed and Dr. Raveendhara Bannuru and featured presentations by Dr. Vanita Aroda, Dr. Dennis Bruemmer, Dr. Eric Johnson, Dr. Grazia Aleppo, Dr. Kenneth Cusi and Dr. Adham Abdel Mottalib on updates in ADA-2023 standards of care in diabetes.
Key points highlighted during this session included:

<ul>
 <li>Dr. El Sayed, and Dr. Bannuru opened the session by providing an overview of methodology used in developing and updating Standard of Care (SOC) with 2 key updates being made in&nbsp;<a href="https://diabetesjournals.org/care/article/46/Supplement_1/S41/148039/3-Prevention-or-Delay-of-Diabetes-and-Associated" rel="noreferrer" target="_blank">section 3 of SOC</a>&nbsp;with respect to prevention and delay of T1D and T2D with inclusion of the recently approved&nbsp;<a href="https://twitter.com/ada_diabetespro/status/1672991697968730118?s=48&amp;t=dM9P7dtzJmQlbQwXCrc7fA" rel="noreferrer" target="_blank">teplizumab</a>&nbsp;to delay the onset of T1D and in&nbsp;<a href="https://diabetesjournals.org/care/article/46/Supplement_1/s49/148058/4-Comprehensive-Medical-Evaluation-and-Assessment" rel="noreferrer" target="_blank">section 4 in SOC</a>&nbsp;with respect to NAFLD (nonalcoholic fatty liver disease). 
 &nbsp;</li>
 <li>Dr. Aroda, presented information on heterogenous progression of pre-diabetes to T2D, where elderly individuals had less progression compared to younger and more obese cohort from pre-diabetes to T2D which can be attributed to different phenotypes (ARIC study). 
 &nbsp;</li>
 <li>The updates to ADA’s SOC in section 3.2 are use of more precise language to identify higher risk for diabetes (e.g., BMI&gt;35, higher glycemic indices). Further, the pre-diabetes pharmacotherapy should include weight loss and decrease CV risk and inclusion of pioglitazone after stroke or TIA (IRIS study) in PwD.</li>
</ul>

<ul>
 <li>Dr. Bruemmer discussed findings from key trials on BP and lipids (ACCORD, SPRINT, STEP, Heart Protection Study) and refresher on goals of therapy which included BP &lt; 130/80, lipid levels and use of high intensity statins. 
 &nbsp;</li>
 <li>The review on secondary prevention was showcased with role of PCSK9 inhibitors and corresponding studies (ODYSSEY_&nbsp;<a href="https://academic.oup.com/eurheartj/article/41/44/4245/5922803?login=true" rel="noreferrer" target="_blank">Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial | European Heart Journal | Oxford Academic (oup.com)</a>) and ezetimibe with mention of AACE and ESC goal (LDL &lt;55). The discussion further added information on diabetes medication with the role of GLP-1s and SGLT-2s and its cardiorenal effects. 
 &nbsp;</li>
 <li>Dr. Johnson informed the audience about the role and importance of Community Health Care Workers and use of person-centered language example use of term “Person with diabetes” or “PwD” instead of “diabetic”.</li>
</ul>

<h2>The New Normal Corner</h2>
<h4>A 360-Degree Examination of Type 1 Diabetes: From Patient Identification to Treatment and Prevention</h4>
Numerous sessions addressed screening and immunotherapy for T1D.

In a joint ADA/JDRF symposium&nbsp;chaired by Sanjoy Dutta, Anette-Gabriele Ziegler, Cristy Geno Rasmussen and Riita Veijola discussed diabetes screening and monitoring perspectives from Germany, the USA and Northern Europe.
Key points highlighted during this session included:
<ul>
 <li>To optimize sensitivity and positive predictive value for detecting T1D during childhood and adolescence, the optimal ages to screen for T1D are 2, 6, and 10 years. Indeed, screening at ages 2 and 6 years results in 82% sensitivity7. 
 &nbsp;</li>
 <li>Due to variability in testing methods, post-infusion monitoring needs to be individualized. Autoimmunity Screening for Kids (ASK) study mentions that A1C is a specific but not sensitive indicator for diagnosis of early T1D, especially in children8. 
 &nbsp;</li>
 <li>DiaUnion in Sweden and Denmark initiated screening for islet autoimmunity in the general childhood population (<a href="https://diaunion.org/en/" rel="noreferrer" target="_blank">DiaUnion – Research in Diabetes and Autoimmunity</a>).</li>
</ul>

In another panel discussion chaired by Dr. Ellen W Leschek, the panelists presented their perspectives on the use of immunotherapies from various settings.
Key points highlighted during this session:
Dr. Leschek presented a brief overview of the TN-10 study9&nbsp;and discussed future needs focusing on pediatric indications and looking at combination therapies. She also discussed barriers including operational and cost.
Dr. Herold provided an update on the TN-10 trial10&nbsp;showing that participants continue to show a 52 months delay&nbsp;versus&nbsp;27 months delay in the placebo group. Dr. Herold mentioned that there is a transient reduction in the number of circulating T-cells, but the cell number was back to baseline values after 6 weeks of treatment. He also highlighted that people with a high proinsulin to C-peptide ratio were likely to progress to stage 3 T1D faster than those with a lower ratio. However, these participants showed a more robust response to teplizumab.

American Diabetes Association: 83rd Scientific Sessions


In deze video vertelt Prof. Snoek over de relatie tussen het hebben van Diabetes en de mentale gezondheid van de diabetespatiënt. Dit doet hij door middel van resultaten uit studies en onderzoeken.

Video Prof. Snoek Diabetes & Mental Health

In deze webinar van 1 uur spreken prof. dr. Frank Snoek, dr. Ileana Pina en dr. Torild Skrivarhaug over de mentale impact van diabetes. De moderator van de webinar is dr. Manuel Castro Cabezas. De webinar is in het Engels.

Mental Health Webinar

Heeft u vragen of wilt u meer weten? Wij zorgen dat u zo snel mogelijk geholpen wordt.

Wij staan klaar

Voor uw intercontext, meld u aan bij uw account Sanofi Campus. Geef uw e-mail door aan uw e-mail.

Als u onze eerste e-mail op {email} tot bevestig uw account u kunt hieronder een nieuwe aanvragen. Als je het niet ziet, moet je mogelijk je spammap controleren.

Deze informatie wordt alleen gebruikt om uw account te valideren en wordt niet verspreid.

titel

Title

This website is for healthcare professionals only.

Welcome to BP Sanofi Campus

Create new password

Om u een gepersonaliseerde ervaring te bieden, moet u

Je profiel is onvolledig

De ADCT geeft een indicatie van hoe gecontroleerd het eczeem is. Beantwoord deze 6 eenvoudige vragen met uw patiënt om de ADCT-score te vinden. Het zal de juiste handelwijze aangeven.

Atopische dermatitis, een vorm van eczeem, kan het leven van uw patiënt op meer manieren beïnvloeden dan u weet.

Doe de atopische dermatitis controle test (ADCT)

Geniet van meer exclusieve inhoud{newline}door <a>door u vandaag te registreren</a>

Heb je al een account? <a>Hier inloggen</a>

Best practices voor het optimaliseren van de patiëntenzorg

Krijg een aangepast beeld van de onderwerpen waarin u geïnteresseerd bent, samen met de mogelijkheid om inhoud op te slaan om op een later tijdstip te bekijken of te lezen.

Onbeperkte toegang tot eersteklas inhoud, whitepapers, casestudy's, onderzoekspapers, webinars, training en up-to-date wetenschappelijke medische bronnen.

Gepersonaliseerde inhoud op basis van uw interessegebieden

Maak contact en blijf up-to-date met collega's op uw vakgebied en onderwerpen die u interesseren via gratis evenementen en leidinggevende forums.

Registreer om het volledige artikel te lezen.

Wij respecteren uw privacy en zullen uw informatie niet delen met derden.

Actuele gidsen die speciaal voor patiënten zijn geschreven

Onbeperkte toegang tot de nieuwste patiëntengidsen en bronnen. Deel inhoud met uw patiënten met gebruiksvriendelijke online tools.

Please complete your profile to read the content.

Your profile is not validated yet. Please verify your inbox.

Beperkte toegang

We can't find the page you're looking for

You are going to a website that is not operated by Sanofi. Sanofi has no control over the content or availability of linked sites or resources, and accepts no liability or responsibility for them or for any loss or damage that may arise from your use of them. Please ensure that you read the legal and privacy policy sections of any third-party site to which you link.

You are about to leave Sanofi Campus website.

You are now leaving this site to visit a partner website.

Thank you for visiting COPD Sanofi Campus.

Welcome to COPD Sanofi Campus.

Welcome to COPD Sanofi Campus

Welcome to CSU Sanofi Campus

Please refresh the page to access the content

Sorry, something went wrong

Normaal gesproken bieden we een schat aan kenis, maar we konden niet vinden waar je naar op zoek bent.

We konden niet vinden wat je zocht

Sanofi is niet verantwoordelijk voor de inhoud van deze externe website.

U staat op het punt Campus.sanofi/nl te verlaten.

Images from <a>iStockphoto.com</a>, Fotolia.de, <c>gettyimages.de</c>, <d>pexels.com</d> and <e>photocase.de</e> were used for our websites.

Volg ons:

Thank you for registering. Before we get started, we need to confirm your email address to ensure that we have the correct information.

Please follow these steps to complete your registration:

Would you like to receive future text messages about Beyfortus updates?

Sanofi is here to help support your patients, their families, and caregivers. For more information regarding Beyfortus®, call <a.callPhoneNumberBeyfortus>1-855-BEYFORTUS (1-855-239-3678)</a.callPhoneNumberBeyfortus> or sign up below to receive the latest updates via email or text. All fields are required.

Would you like to learn more about Beyfortus® (nirsevimab-alip) 50 mg and 100 mg injection? Leave us your contact details, and a Sanofi representative will be in touch.

Would you also like to receive future messages and updates about Beyfortus?

Do you want to participate in the Beyfortus Reservation Program?

What information are you interested in learning more about? (Optional)

Request a visit from your local ALPROLIX representative to learn more. Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Request a visit from your local ALTUVIIIO representative to learn more. Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Request a visit from your local QFITLIA representative to learn more. Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Sign up to schedule an office visit with your ALPROLIX® Representative or receive updates about ALPROLIX. Please complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Sign up to schedule an office visit with your QFITLIA Representative or receive updates about QFITLIA. Please complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Sanofi biedt u exclusieve content over onze verschillende therapeutische gebieden op één portal speciaal voor professionals in de gezondheidszorg, inclusief wetenschappelijk nieuws, een lijst met evenementen en tools en diensten voor uw dagelijkse praktijk.

Bevestig uw status

De inhoud van deze website is alleen toegankelijk voor geregistreerde gebruikers.

Log in alstublieft

Email verificatie

U ziet een voorbeeld van de portal. Wis uw cookies (bijvoorbeeld door uw browservenster te sluiten) om terug te gaan naar de openbare modus.

We hebben onze privacyverklaring bijgewerkt om je gegevens beter te beschermen en je ervaring te verbeteren. Neem even de tijd om de wijzigingen door te nemen door <privacyNewTab>hier te klikken</privacyNewTab>. Uw privacy is belangrijk voor ons. Klik op doorgaan om te bevestigen dat u de nieuwe privacyverklaring hebt gelezen.

Update van de privacyverklaring

Communicatie toestemming

My consents

Password

Confirm password

{resultsCount, plural, one {resultaat} other {resultaten}}

Log in om toegang te krijgen tot de resultaten

U moet inloggen op uw account om toegang te krijgen tot medische inhoud.

Inloggen

Registreer in minder dan 1 minuut om toegang te krijgen tot de resultaten

U verlaat nu het Sanofi inhoudsgedeelte van onze site en komt in het inhoudsgedeelte voor extern medisch bibliografisch zoeken.

U verlaat nu het externe medische bibliografische zoekgedeelte van onze site en komt in het inhoudsgedeelte van Sanofi.

Diabetes type 2

Events

American Diabetes Association: 83rd Scientific Sessions

Video Prof. Snoek Diabetes & Mental Health

Mental Health Webinar