The UK Prospective Diabetes Study (UKPDS) is a landmark study that has significantly influenced the management of type 2 diabetes (T2D). The study by Stratton et al., published in BMJ in 2000, explores the relationship between glycaemic control and the risk of macrovascular and microvascular complications in patients with T2D. This summary highlights the key findings and their implications for clinical practice.
The UKPDS was a prospective observational study involving 4,585 patients with newly diagnosed T2D. The study aimed to determine how long-term glycaemic control, measured by HbA1c levels, affects the incidence of various diabetic complications. Data were collected over a median follow-up period of 10 years.
<h2>Key Highlights</h2>
<ol>
 <li>Risk Reduction: 
 Each 1% reduction in updated mean HbA1c was associated with significant reductions in the risk of complications: 
 &nbsp; 
 <ul>
 <li>21% reduction in any diabetes-related endpoint.</li>
 <li>21% reduction in diabetes-related deaths.</li>
 <li>14% reduction in myocardial infarction.</li>
 <li>37% reduction in microvascular complications.</li>
 </ul></li>
</ol>

<ol>
 <li>Hide</li>
 <li>No Threshold Effect: 
 The study found no specific HbA1c threshold below which the risk of complications markedly decreased. Instead, the risk of complications continuously decreased with lower HbA1c levels. 
 &nbsp;</li>
 <li>Consistent Benefits: 
 The benefits of improved glycaemic control were consistent across different types of complications, emphasizing the importance of maintaining lower HbA1c levels to reduce overall risk.</li>
</ol>

The UKPDS demonstrates that better glycaemic control significantly reduces the risk of both macrovascular and microvascular complications in patients with T2D. The findings support the goal of achieving and maintaining lower HbA1c levels to minimize the risk of complications and improve patient outcomes.

<h2>Clincal implications for General Practice</h2>
Healthcare providers should focus on:

Strive to maintain HbA1c levels as low as safely possible to reduce the risk of complications.

Conduct frequent HbA1c testing to ensure glycaemic targets are met.

Implement a holistic approach to diabetes care, including lifestyle modifications, patient education, and appropriate pharmacotherapy.

By prioritizing these strategies, healthcare providers can help patients with T2D achieve better glycaemic control and reduce the incidence of diabetes-related complications.

TYPE-2-DIABETES

DIABETES

READ THE FULL STUDY HERE

Heeft u vragen of wilt u meer weten? Wij zorgen dat u zo snel mogelijk geholpen wordt.

Wij staan klaar

Summary of The UK Prospective Diabetes Study (UKPDS).

How Does Glycaemic Control Impact Complications in Type 2 Diabetes?

Type 2 diabetes (T2D) remains a significant global health challenge, particularly in developing countries. The International Diabetes Management Practices Study (IDMPS) provides valuable real-world evidence on the management and outcomes of T2D over a 12-year period. This article summarizes key findings from the IDMPS, highlighting trends in glycaemic control, therapy use, and care practices.

<h2>When to Initiate Basal Insulin?</h2>
The IDMPS collected data from 66,088 individuals with T2D across 49 countries, involving 6099 physicians. The study spanned seven cross-sectional waves from 2005 to 2017, with each physician collecting data from ten consecutive patients during a two-week period.
<h2>Key Findings</h2>
<ol>
 <li>Glycaemic Control: 
 The proportion of participants achieving HbA1c &lt;7% decreased from 36% in 2005 to 30.1% in 2017. This decline underscores persistent challenges in achieving optimal glycaemic control. 
 &nbsp;</li>
 <li>Therapy Use: 
 Over 80% of participants were on oral glucose-lowering drugs (OGLDs), with a notable decline in sulfonylurea use. Insulin use increased from 32.8% to 41.2%, with a slight reduction in the time to insulin initiation. 
 &nbsp;</li>
 <li>Diabetes Education: 
 The proportion of participants receiving diabetes education rose from 59.0% to 78.3%, reflecting an increased emphasis on patient education and self-management. 
 &nbsp;</li>
 <li>Monitoring: 
 The frequency of HbA1c measurements improved significantly, with 92.9% of participants having at least two measurements within 12 months by the final wave.</li>
</ol>

Despite advancements in diabetes management, glycaemic control in developing countries remains suboptimal. The IDMPS highlights the need for systemic changes and better organization of care to improve outcomes for individuals with T2D. Enhanced diabetes education, timely therapy adjustments, and regular monitoring are crucial for achieving better glycaemic control and reducing the burden of diabetes-related complications.

<h2>Clincal implications for General Practice</h2>
Healthcare providers play a pivotal role in managing T2D. The findings from the IDMPS emphasize the importance of:

Ensuring frequent HbA1c testing to track glycaemic control.

Providing comprehensive diabetes education to empower patients in self-management.

Tailoring treatment plans to individual patient needs, including timely initiation and adjustment of insulin therapy.

By addressing these areas, healthcare providers can significantly improve the quality of care for patients with T2D, ultimately leading to better health outcomes.
This summary provides a concise overview of the IDMPS findings and their implications for healthcare providers. For more detailed information, refer to the original article by Aschner et al. in Diabetologia.

Summary of Aschner P, et al. Diabetologia. 2020;63(4):711-721.

Why is Glycaemic Control in Type 2 Diabetes Still a Challenge?

<h2>Type 1 diabetes: Detect early and follow up for a soft landing</h2>

The Sanofi symposium on the advancements in the detection of the early stages of T1D helped provide a deeper understanding of the disease and raise awareness on early detection strategies in T1D1.
This Sanofi symposium chaired by Chantal Mathieu, featured presentations by Colin Dayan, Emanuele Bosi, Sanjoy Dutta, and Chantal Mathieu, focusing on the importance of staging individuals with T1D.

From: Hendriks AEJ, Marcovecchio ML, Besser REJ, et al. Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes. Diabetes Metab Res Rev. 2024;40(2):e3777. doi:10.1002/dmrr.3777.

Prof. Dayan started his speech by highlighting that T1D is a chronic autoimmune disease with metabolic outcomes. He noted that the progression of T1D is often accompanied by anti-islet antibodies (IAA, IA2, GADA and ZnT8A), and person living with diabetes tested positive for ≥2 autoantibodies with dysglycemia are highly likely to progress to stage 3 T1D2. The progression is more rapid in younger population (&lt;12 years) than in adults3.
Interestingly, in another session devoted to the mechanisms of T1D onset, Dr. Roberto Mallone highlighted the need to explore autoimmunity biomarkers beyond autoantibodies, with a specific focus on T cell biomarkers. Notably, autoimmune CD8+ T cells, activated by HLA molecules, are implicated in the disease’s pathogenesis4.

In addition, the complexity of T1D using insights from organ donors, challenges traditional views and highlights the role of pancreatic pathology and the need for deeper understanding. Advanced technologies offer insights into insulitis, beta cell dysfunction, and exocrine pancreatic involvement5,6.
Prof. Bosi highlighted that screening for T1D autoantibodies reduces the risk of DKA and associated complications, as evident in Fr1da and DPV registry, and provides an opportunity to HCPs to educate the patient and caregivers and allow for a soft landing into the disease7,8. Several screening initiatives are occurring worldwide, with Italy being the first country to implement a general population screening approach to T1D and celiac disease in children and adolescents.

Early screening and monitoring for T1D can reduce the psychological burden of diagnosis8. However, awareness among HCPs or families, as well as access to screening, remains low and is the primary barrier to screening programs. Dr. Dutta noted that JDRF is working to expand screening and provide support systems to HCPs through conferences, clinic-based training, and upcoming consensus guidelines. A draft of these guidelines was presented earlier that day at ATTD so stay tuned for the publication in the upcoming months. In the meantime, please feel free to consult the Clinical care advice for monitoring of islet autoantibody positive individuals with early stage type 1 diabetes recently published by the INNODIA consortium, Fr1da and GPPAD study groups (<a href="https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3777" target="_blank">Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes - Hendriks - 2024 - Diabetes/Metabolism Research and Reviews - Wiley Online Library</a>).

<h4>References:</h4>
<ol>
 <li>
 Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care. 2015;38(10):1964-1974. doi:10.2337/dc15-1419</li>
 <li>
 Besser REJ, Bell KJ, Couper JJ, et al. ISPAD Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents. Pediatr Diabetes. 2022;23(8):1175-1187. doi:10.1111/pedi.13410</li>
 <li>
 Redondo MJ, van Raalte DH. Age Ain't Nothing But a Number . . . or Is It?. Diabetes Care. 2023;46(6):1135-1136. doi:10.2337/dci23-0013</li>
 <li>
 Samassa F, Mallone R. Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective. Curr Opin Endocrinol Diabetes Obes. 2022;29(4):370-378. doi:10.1097/MED.0000000000000735</li>
 <li>
 Leete P, Morgan NG. Footprints of Immune Cells in the Pancreas in Type 1 Diabetes; to "B" or Not to "B": Is That Still the Question?. Front Endocrinol (Lausanne). 2021;12:617437. Published 2021 Feb 25. doi:10.3389/fendo.2021.617437</li>
 <li>
 Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E. Structure and function of the exocrine pancreas in patients with type 1 diabetes. Rev Endocr Metab Disord. 2019;20(2):129-149. doi:10.1007/s11154-019-09501-3</li>
 <li>
 Hummel S, Carl J, Friedl N, et al. Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Diabetologia. 2023;66(9):1633-1642. doi:10.1007/s00125-023-05953-0</li>
 <li>
 Ziegler AG, Kick K, Bonifacio E, et al. Yield of a Public Health Screening of Children for Islet Autoantibodies in Bavaria, Germany. JAMA. 2020;323(4):339-351. doi:10.1001/jama.2019.21565</li>
</ol>

<h2>Exploring artificial intelligence in diabetes care: Optimizing health and sports performance</h2>

Artificial Intelligence technologies such as closed-loop systems and continuous glucose monitoring (CGM) systems, can enhance diabetes management and quality of life, and are even used to boost sports performance for both individuals with and without diabetes.
With the capability to measure glucose levels in the interstitial fluid, CGM can provide insights into an individual’s metabolism and energy levels during physical activity. CGM aids in developing options for managing glucose levels in people living with diabetes during exercise, such as consuming small amounts of carbohydrates before hypoglycemia occurs. Ongoing efforts to improve technology accuracy and the development of digital apps have led to the widespread adoption of CGM technology, even among athletes without diabetes, to optimize their performance and nutrition.
More generally, discussions delved into how these technologies can improve diabetes management and enhance quality of life. Studies showcased positive outcomes, such as increased time in range and reductions in hyperglycemia and hypoglycemia, emphasizing the potential of these innovations to address health disparities. Highlighting the importance of considering ethnic and socioeconomic factors in decision-making, the talks underscored the need for advocacy for evidence-based guidelines and collaboration with health organizations to ensure equitable access to these innovations for people living with diabetes.

TYPE-1-DIABETES

Highlights ATTD 2024

<h2>Orion studie</h2>
De ORION-studie was een prospectief, observationeel onderzoek dat in 11 landen werd&nbsp;uitgevoerd met 493 deelnemers ouder dan 18 jaar met diabetes type 2. De deelnemers werden&nbsp;ten minste acht weken voorafgaand aan de studie behandeld met glargine-300 en werden over drie&nbsp;tijdsperioden beoordeeld: pre-ramadan (1-3 maanden ervoor), tijdens de ramadan (1 maand) en&nbsp;post-ramadan (1 maand erna).1

INTEGRATED-DIABETES-CARE

LEES HIER DE HELE PUBLICATIE

Ondanks de mogelijkheid voor een medische uitzondering, bleek uit een groot wereldwijd onderzoek dat vier van de tien moslims met diabetes type 1 en acht van de tien moslims met diabetes type 2 meer dan vijftien dagen vasten tijdens de ramadan.2

Diabetes en ramadan: ORION studie

Voor uw intercontext, meld u aan bij uw account Sanofi Campus. Geef uw e-mail door aan uw e-mail.

Als u onze eerste e-mail op {email} tot bevestig uw account u kunt hieronder een nieuwe aanvragen. Als je het niet ziet, moet je mogelijk je spammap controleren.

Deze informatie wordt alleen gebruikt om uw account te valideren en wordt niet verspreid.

titel

Title

This website is for healthcare professionals only.

Welcome to BP Sanofi Campus

Create new password

Om u een gepersonaliseerde ervaring te bieden, moet u

Je profiel is onvolledig

De ADCT geeft een indicatie van hoe gecontroleerd het eczeem is. Beantwoord deze 6 eenvoudige vragen met uw patiënt om de ADCT-score te vinden. Het zal de juiste handelwijze aangeven.

Atopische dermatitis, een vorm van eczeem, kan het leven van uw patiënt op meer manieren beïnvloeden dan u weet.

Doe de atopische dermatitis controle test (ADCT)

Geniet van meer exclusieve inhoud{newline}door <a>door u vandaag te registreren</a>

Heb je al een account? <a>Hier inloggen</a>

Best practices voor het optimaliseren van de patiëntenzorg

Krijg een aangepast beeld van de onderwerpen waarin u geïnteresseerd bent, samen met de mogelijkheid om inhoud op te slaan om op een later tijdstip te bekijken of te lezen.

Onbeperkte toegang tot eersteklas inhoud, whitepapers, casestudy's, onderzoekspapers, webinars, training en up-to-date wetenschappelijke medische bronnen.

Gepersonaliseerde inhoud op basis van uw interessegebieden

Maak contact en blijf up-to-date met collega's op uw vakgebied en onderwerpen die u interesseren via gratis evenementen en leidinggevende forums.

Registreer om het volledige artikel te lezen.

Wij respecteren uw privacy en zullen uw informatie niet delen met derden.

Actuele gidsen die speciaal voor patiënten zijn geschreven

Onbeperkte toegang tot de nieuwste patiëntengidsen en bronnen. Deel inhoud met uw patiënten met gebruiksvriendelijke online tools.

Please complete your profile to read the content.

Your profile is not validated yet. Please verify your inbox.

Beperkte toegang

We can't find the page you're looking for

You are going to a website that is not operated by Sanofi. Sanofi has no control over the content or availability of linked sites or resources, and accepts no liability or responsibility for them or for any loss or damage that may arise from your use of them. Please ensure that you read the legal and privacy policy sections of any third-party site to which you link.

You are about to leave Sanofi Campus website.

You are now leaving this site to visit a partner website.

Thank you for visiting COPD Sanofi Campus.

Welcome to COPD Sanofi Campus.

Welcome to COPD Sanofi Campus

Please refresh the page to access the content

Sorry, something went wrong

Normaal gesproken bieden we een schat aan kenis, maar we konden niet vinden waar je naar op zoek bent.

We konden niet vinden wat je zocht

Sanofi is niet verantwoordelijk voor de inhoud van deze externe website.

U staat op het punt Campus.sanofi/nl te verlaten.

Volg ons:

Thank you for registering. Before we get started, we need to confirm your email address to ensure that we have the correct information.

Please follow these steps to complete your registration:

Would you like to receive future text messages about Beyfortus updates?

Sanofi is here to help support your patients, their families, and caregivers. For more information regarding Beyfortus®, call <a.callPhoneNumberBeyfortus>1-855-BEYFORTUS (1-855-239-3678)</a.callPhoneNumberBeyfortus> or sign up below to receive the latest updates via email or text. All fields are required.

Would you like to learn more about Beyfortus® (nirsevimab-alip) 50 mg and 100 mg injection? Leave us your contact details, and a Sanofi representative will be in touch.

Would you also like to receive future messages and updates about Beyfortus?

Do you want to participate in the Beyfortus Reservation Program?

What information are you interested in learning more about? (Optional)

Request a visit from your local ALPROLIX representative to learn more. Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Request a visit from your local ALTUVIIIO representative to learn more. Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Request a visit from your local QFITLIA representative to learn more. Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Sign up to schedule an office visit with your ALPROLIX® Representative or receive updates about ALPROLIX. Please complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Sign up to schedule an office visit with your QFITLIA Representative or receive updates about QFITLIA. Please complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>. All fields are required.

Sanofi biedt u exclusieve content over onze verschillende therapeutische gebieden op één portal speciaal voor professionals in de gezondheidszorg, inclusief wetenschappelijk nieuws, een lijst met evenementen en tools en diensten voor uw dagelijkse praktijk.

Bevestig uw status

De inhoud van deze website is alleen toegankelijk voor geregistreerde gebruikers.

Log in alstublieft

Email verificatie

U ziet een voorbeeld van de portal. Wis uw cookies (bijvoorbeeld door uw browservenster te sluiten) om terug te gaan naar de openbare modus.

We hebben onze privacyverklaring bijgewerkt om je gegevens beter te beschermen en je ervaring te verbeteren. Neem even de tijd om de wijzigingen door te nemen door <privacyNewTab>hier te klikken</privacyNewTab>. Uw privacy is belangrijk voor ons. Klik op doorgaan om te bevestigen dat u de nieuwe privacyverklaring hebt gelezen.

Update van de privacyverklaring

Communicatie toestemming

My consents

Password

Confirm password

{resultsCount, plural, one {resultaat} other {resultaten}}

Log in om toegang te krijgen tot de resultaten

U moet inloggen op uw account om toegang te krijgen tot medische inhoud.

Inloggen

Registreer in minder dan 1 minuut om toegang te krijgen tot de resultaten

U verlaat nu het Sanofi inhoudsgedeelte van onze site en komt in het inhoudsgedeelte voor extern medisch bibliografisch zoeken.

U verlaat nu het externe medische bibliografische zoekgedeelte van onze site en komt in het inhoudsgedeelte van Sanofi.

Diabetes type 2

Voor zorgverleners

How Does Glycaemic Control Impact Complications in Type 2 Diabetes?

Why is Glycaemic Control in Type 2 Diabetes Still a Challenge?

Highlights ATTD 2024

Diabetes en ramadan: ORION studie