<h2>Voedselherintroductie bij EoE</h2>
<p>Eosinofiele Oesofagitis, EoE, is een chronische type 2 ontstekingsziekte waarbij symptomen vaak verergerd worden door voedingsmiddelen zoals melk, tarwe, eieren, en soja. Een behandelmogelijkheid voor EoE is om deze voedingsstoffen uit het dieet van de patiënt te schrappen, een zogenaamd eliminatiedieet. Voor patiënten is het moeilijk zich aan deze diëten te houden. EoE heeft grote impact op de kwaliteit van leven<sup>1</sup>. Veel patiënten vermijden bepaalde voedingsmiddelen of passen hun eetgedrag aan om klachten te voorkomen<sup>2</sup>.</p>
<p>Recent onderzoek toont aan dat dupilumab niet alleen de ontsteking en klachten vermindert, maar ook voedselherintroductie mogelijk maakt<sup>3</sup>.</p>
<p>Benieuwd naar wat deze resultaten precies laten zien en hoe ze benadrukken dat het behandeldoel bij EoE verder gaat dan alleen klachtenvermindering? Bekijk de video!</p>

SPECIALTY-CARE

DUPIXENT

EOSINOPHILIC-ESOPHAGITIS-EOE

GASTROENTEROLOGY

Nieuwe inzichten in EoE en voedselherintroductie met dupilumab

<p><strong>Aflevering en vergoeding:</strong> U.R. Financiering verloopt via add-on. Voor prijzen zie de Z-index taxe.</p>

<p>Referenties</p>

<p>Heeft u vragen of wilt u meer weten? Wij zorgen dat u zo snel mogelijk geholpen wordt.</p>


Wij staan klaar

<p>Airway remodeling drives progressive and potentially irreversible lung function decline in asthma.<sup>2</sup> Understanding the central role of IL-4 and IL-13 in this process is essential to guiding effective treatment strategies.<sup>1,10</sup></p>

<h3>Listen to Prof. Alberto Papi about Airway remodeling</h3>

<h2>Understanding airway remodeling and hyperresponsiveness<sup>1,3-5</sup></h2>
<p>Asthma involves chronic airway inflammation, structural changes in the lung airway lining, and exaggerated airway constriction in response to stimuli.<sup>3,4</sup> These processes — airway remodeling and airway hyperresponsiveness (AHR) — are the key underlying mechanisms of lung function decline.<sup>1,5</sup></p>

<figure class="table" style="width:100%;">
 <table style="background-color:#23004c;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#23004c;border-color:#fff;padding:20px;">
     <h3><span style="color:hsl(0,0%,100%);">Type 2 inflammation, Hyperresponsiveness, and Remodeling contribute to Airway narrowing<sup>6</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<p>What is airway remodeling?</p>

<h3 style="text-align:center;">Remodeling in asthma comprises structural changes to the airways<sup>10-13</sup></h3>

<p>What is airway hyperresponsiveness?</p>

<figure class="table" style="width:100%;">
 <table style="background-color:#23004c;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#7A00E6;border-color:#7A00E6;padding:10px;text-align:center;">
     <h3><span style="color:hsl(0,0%,100%);">Key clinical insight</span></h3></td>
   </tr>
   <tr>
    <td style="background-color:#23004c;border-color:#23004c;padding:20px;">
     <h3><span style="color:hsl(0,0%,100%);">AHR is associated with increased risk of lung function decline, persistence of symptoms such as wheezing, and occurrence of future exacerbations. Treatment strategies focused on normalization of AHR can reduce exacerbation risk and prevent further airway inflammation and remodeling.<sup>5</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<h2>The role of type 2 inflammation<sup>10</sup></h2>
<p>Majority of patients with asthma have <strong>type 2 inflammation</strong> as the main causative pathophysiologic process.<sup>10</sup> This type of asthma is driven by type 2 cytokines (primarily IL-4, IL-13, and IL-5) with additional contributions from alarmins like thymic stromal lymphopoietin (TSLP), an epithelial-derived regulator of type 2 inflammation.<sup>10</sup></p>

<h3>How type 2 cytokines drive asthma pathology?<sup>1-2,10-11</sup></h3>

<p>IL-4 and IL-13 facilitate migration and adhesion of eosinophils in the lung airways, stimulate mucus hypersecretion, promote AHR, and directly drive airway remodeling.<sup>1,11</sup></p>

<p>IL-5 mediates eosinophil differentiation in the bone marrow and their subsequent activation in the airways to promote airway inflammation.<sup>1</sup></p>

<p>Alarmins (TSLP and IL33) function as regulators, amplifying the type 2 inflammatory cascade from the epithelial level.<sup>10,11</sup></p>

<p>The cumulative action of IL-4 and IL-13 causes edema, mucus hypersecretion, AHR, and airway remodeling - ultimately leading to decreased lung function.<sup>10</sup></p>

<figure class="table" style="width:100%;">
 <table style="background-color:#23004c;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#7A00E6;border-color:#7A00E6;padding:10px;text-align:center;">
     <h3><span style="color:hsl(0,0%,100%);">Did you know?</span></h3></td>
   </tr>
   <tr>
    <td style="background-color:#23004c;border-color:#23004c;padding:20px;">
     <h3><span style="color:hsl(0,0%,100%);">Eosinophils are NOT the primary drivers of airway remodeling. IL-4 and IL-13 are the cytokines mainly responsible for the structural airway changes that lead to lung function decline. Addressing these cytokines is essential to halt lung damage.<sup>1,2</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<p>More info about the role of T2 cytokines in airway remodeling<sup>1,10</sup></p>

<h2>IL-4 and IL-13: The critical therapeutic targets<sup>1,8,9</sup></h2>
<p>While eosinophil count and IL-5 are important markers of asthma exacerbations, IL-4 and IL-13 are the primary drivers of the structural airway changes seen in remodeling.<sup>2</sup> Therapeutic approaches targeting IL-4 and IL-13 can address both the inflammatory cascade and the underlying remodeling processes that contribute to lung function decline.<sup>2</sup></p>
<p>Research evidence supports the direct role of IL-4 and IL-13 in airway inflammation, AHR, and airway remodeling — making them critical therapeutic targets.<sup>1,8,9</sup></p>

<h3 style="text-align:center;">Comparison of therapeutic targets</h3>
<figure class="table" style="width:100%;">
 <table>
  <tbody>
   <tr>
    <td style="background-color:#23004c;border-color:#fff;text-align:center;width:30%;">
     <h3><span style="color:hsl(0,0%,100%);">Target</span></h3></td>
    <td style="background-color:#23004c;border-color:#fff;text-align:center;width:35%;">
     <h3><span style="color:hsl(0,0%,100%);">Mechanism</span></h3></td>
    <td style="background-color:#23004c;border-color:#fff;text-align:center;width:35%;">
     <h3><span style="color:hsl(0,0%,100%);">Impact on Airway Remodeling</span></h3></td>
   </tr>
   <tr>
    <td style="border-color:#000;"><strong>IL-4 &amp; IL-13<sup>1,2,9</sup></strong></td>
    <td style="border-color:#000;">Drive airway inflammation, eosinophil migration and adhesion, mucus hypersecretion, and AHR.</td>
    <td style="border-color:#000;">Direct — address the root cause of remodeling and lung function decline.</td>
   </tr>
   <tr>
    <td style="border-color:#000;"><strong>IL-5<sup>1,2</sup></strong></td>
    <td style="border-color:#000;">Mediates eosinophil differentiation in bone marrow and activation in airways.</td>
    <td style="border-color:#000;">Secondary role — influences remodeling through eosinophil-mediated inflammatory processes.</td>
   </tr>
  </tbody>
 </table>
</figure>
<p>Blocking IL-4 and IL-13 can also suppress eosinophilic inflammation indirectly — reducing airway tissue eosinophilia.<sup>1</sup></p>

<figure class="table" style="width:100%;">
 <table style="background-color:#23004c;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#7A00E6;border-color:#7A00E6;padding:10px;text-align:center;">
     <h3><span style="color:hsl(0,0%,100%);">Key message</span></h3></td>
   </tr>
   <tr>
    <td style="background-color:#23004c;border-color:#23004c;padding:20px;">
     <h3><span style="color:hsl(0,0%,100%);">Blocking IL-4 and IL-13 can reduce airway tissue eosinophilia, decrease immune infiltrates associated with type 2 inflammation, and extend therapeutic benefits beyond eosinophil count reduction alone.<sup>1,2</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<h2>Clinical implications: The importance of early intervention<sup>7</sup></h2>
<p>Airway remodeling is a progressive process. Early detection and intervention targeting the underlying inflammatory drivers can reduce acute asthma attacks and minimize irreversible lung function decline.<sup>7</sup></p>
<p>Identifying the type of inflammation present in each patient is key to effective disease management.</p>
<p>The following <strong>type 2 inflammation biomarkers</strong> should be assessed:<sup>7</sup></p>
<ul>
 <li><strong>Blood eosinophil count</strong> — elevated levels indicate eosinophilic airway inflammation</li>
 <li><strong>Fractional exhaled nitric oxide (FeNO)</strong> — a marker of IL-13-driven airway inflammation</li>
 <li><strong>Serum IgE</strong> — elevated in allergic/type 2-driven asthma</li>
</ul>
<p>Early biomarker assessment enables physicians to identify patients at highest risk of remodeling and to select treatment strategies that target the root cause of disease progression.<sup>7</sup></p>

<figure class="table" style="width:100%;">
 <table style="background-color:#23004c;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#7A00E6;border-color:#7A00E6;padding:10px;text-align:center;">
     <h3><span style="color:hsl(0,0%,100%);">Clinical action</span></h3></td>
   </tr>
   <tr>
    <td style="background-color:#23004c;border-color:#23004c;padding:20px;">
     <h3><span style="color:hsl(0,0%,100%);">Identify your patients at risk of airway remodeling — assess type 2 inflammation biomarkers early. Proactive phenotyping and targeted intervention can improve the trajectory of disease progression.<sup>7</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<h3>Listen to Prof. Alberto Papi about the importance of early intervention</h3>

Airway remodeling in asthma: Why targeting IL-4 and IL-13 matters

ASTHMA

RESPIRATORY

<p data-font="small">▼ This medicinal product is subject to additional monitoring.</p>
<p>Beyfortus<sup>®</sup> is indicated for the prevention of Respiratory Syncytial Virus (RSV) lower respiratory tract disease in:<sup>1</sup></p>
<ul>
 <li>Neonates and infants during their first RSV season;</li>
 <li>Children up to 24 months of age who remain vulnerable to severe RSV disease through their second RSV season.</li>
</ul>
<p>Beyfortus<sup>®</sup> should be used in accordance with official recommendations.<sup>1</sup></p>

<h2>Beyfortus<sup>® </sup>has an unparalleled body of real-world evidence against RSV disease, including hospitalizations<sup>2–60</sup></h2>

<figure class="table" style="width:100%;">
 <table style="background-color:#7e81d2;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#7e81d2;border-color:#fff;padding:10px;">
     <h3><span style="color:hsl(0,0%,100%);">&gt; 50 real-world studies in over 400,000 Beyfortus<sup>®</sup>-immunized infants across the Northern and Southern Hemispheres<sup>*,2-60</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<h2>A meta-analysis of 27 studies assessed the effectiveness of Beyfortus<sup>®</sup> against RSV-related outcomes in the real world<sup>61</sup></h2>
<p>The 27 studies included after screening/eligibility, was conducted in Spain, France, US, Italy and Luxembourg. Beyfortus<sup>®</sup> was associated with high effectiveness against RSV-related outcomes<sup>61</sup>:</p>

<p data-font="small">Length of hospital stay: No difference between Beyfortus<sup>®</sup>-immunized infants and non-immunized infants was observed (weighted mean difference [WMD]: 0.10; 95% CI: -0.63–0.65; p=0.97)</p>

<h2>The NIRSE-GAL study: A real-world effectiveness and impact study from Galicia, Spain<sup>60</sup></h2>
<p>Galicia, a region in northwestern Spain, became one of the first places in the world to introduce nirsevimab as part of its regional immunization program for infants. The study was conducted between September 25, 2023, and ended March 31, 2024. It included over 13,300 infants.<sup>2,60</sup></p>

<figure class="table" style="width:100%;">
 <table style="background-color:#c065ba;border-color:#fff;border-style:solid;">
  <tbody>
   <tr>
    <td style="background-color:#c065ba;border-color:#fff;padding:10px;">
     <h3><span style="color:hsl(0, 0%, 100%);">After Beyfortus<sup>®</sup> implementation, RSV LRTI hospitalization decreased substantially by 89,2%<sup>¶</sup> vs. five previous seasons for infants in the overall cohort (infants born before and during RSV season).<sup>60</sup></span></h3></td>
   </tr>
  </tbody>
 </table>
</figure>

<p>In this real-world study, high coverage was achieved in the seasonal and catch-up groups. High effectiveness and public health impact were seen with Beyfortus. The findings from this study support clinical trial efficacy and safety data.<sup>1,60,62,63</sup></p>
<h3 style="text-align:center;">Watch the video below to learn more about the findings of the study:</h3>

VACCINES

BEYFORTUS

RESPIRATORY-SYNCYTIAL-VIRUS

Beyfortus®▼(nirsevimab): effectiveness and public health impact in the real world

<h3><sup>▼</sup>Beyfortus had a favorable safety profile in clinical trials.<sup>1,62-65</sup></h3>
<p>Safety has been studied in a broad population, including healthy premature infants and children at higher risk of RSV infections of the lower respiratory tract. The type and frequency of adverse reactions with Beyfortus were comparable to placebo in the Phase 2b and Phase 3 studies.<sup>1,62-65</sup></p>

<h3><span style="color:hsl( 186, 100%, 43% );">Rash</span></h3>
<p>within 14 days of dosing</p>

<h3><span style="color:hsl( 238, 48%, 66% );">Pyrexia</span></h3>
<p>within 7 days of dosing</p>

<h3><span style="color:hsl( 304, 42%, 57% );">Injection site reactions</span></h3>
<p>within 7 days of dosing</p>

<p>Hypersensitivity reactions have been spontaneously reported after marketing authorisation; The frequency is unknown.<sup>1</sup></p>
<p>In the study in infants at higher risk of severe RSV, the safety profile of Beyfortus was comparable to that of the comparator medicinal product palivizumab and consistent with the safety profile of nirsevimab in full-term and preterm infants at GA ≥ 29 weeks.<sup>1,62,65</sup></p>

<p>Footnotes</p>

<p>Compulsory Information</p>

<p>Heeft&nbsp;u vragen&nbsp;of wilt u meer weten? Wij zorgen dat&nbsp;u zo snel mogelijk geholpen wordt.</p>

<p><strong>Wij staan klaar</strong></p>

Een platform voor beroepsbeoefenaren om betrouwbare en relevante informatie over onze medicijnen en therapieën te vinden.

Welkom bij Campus Sanofi Nederland

OUT-OF-TAXONOMY

Voor uw intercontext, meld u aan bij uw account Sanofi Campus. Geef uw e-mail door aan uw e-mail.

Als u onze eerste e-mail op <strong>{email}</strong> tot bevestig uw account u kunt hieronder een nieuwe aanvragen. Als je het niet ziet, moet je mogelijk <strong>je spammap</strong> controleren.

Deze informatie wordt alleen gebruikt om uw account te valideren en wordt niet verspreid.

titel

Title

Korte samenvatting

This website is for healthcare professionals only.

Welcome to BP Sanofi Campus

Create new password

Om u een gepersonaliseerde ervaring te bieden, moet u

Je profiel is onvolledig

De ADCT geeft een indicatie van hoe gecontroleerd het eczeem is. Beantwoord deze 6 eenvoudige vragen met uw patiënt om de ADCT-score te vinden. Het zal de juiste handelwijze aangeven.

Atopische dermatitis, een vorm van eczeem, kan het leven van uw patiënt op meer manieren beïnvloeden dan u weet.

Doe de atopische dermatitis controle test (ADCT)

Geniet van meer exclusieve inhoud{newline}door <a>door u vandaag te registreren</a>

Heb je al een account? <a>Hier inloggen</a>

Best practices voor het optimaliseren van de patiëntenzorg

Krijg een aangepast beeld van de onderwerpen waarin u geïnteresseerd bent, samen met de mogelijkheid om inhoud op te slaan om op een later tijdstip te bekijken of te lezen.

Onbeperkte toegang tot eersteklas inhoud, whitepapers, casestudy's, onderzoekspapers, webinars, training en up-to-date wetenschappelijke medische bronnen.

Gepersonaliseerde inhoud op basis van uw interessegebieden

Maak contact en blijf up-to-date met collega's op uw vakgebied en onderwerpen die u interesseren via gratis evenementen en leidinggevende forums.

Registreer om het volledige artikel te lezen.

Wij respecteren uw privacy en zullen uw informatie niet delen met derden.

Actuele gidsen die speciaal voor patiënten zijn geschreven

Onbeperkte toegang tot de nieuwste patiëntengidsen en bronnen. Deel inhoud met uw patiënten met gebruiksvriendelijke online tools.

Please complete your profile to read the content.

Your profile is not validated yet. Please verify your inbox.

Beperkte toegang

Share via {platform} (opens email client)

Cause And Symptoms

Complications

Diagnosis And Treatment

Overview

Prevention

References

We can't find the page you're looking for

You are going to a website that is not operated by Sanofi. Sanofi has no control over the content or availability of linked sites or resources, and accepts no liability or responsibility for them or for any loss or damage that may arise from your use of them. Please ensure that you read the legal and privacy policy sections of any third-party site to which you link.

You are about to leave Sanofi Campus website.

You are now leaving this site to visit a partner website.

Thank you for visiting COPD Sanofi Campus.

Welcome to COPD Sanofi Campus.

Welcome to COPD Sanofi Campus

Welcome to CSU Sanofi Campus

Please refresh the page to access the content

Sorry, something went wrong

Normaal gesproken bieden we een schat aan kenis, maar we konden niet vinden waar je naar op zoek bent.

We konden niet vinden wat je zocht

Sanofi is niet verantwoordelijk voor de inhoud van deze externe website.

U staat op het punt Campus.sanofi/nl te verlaten.

Volg ons:

<strong>Thank you for registering. Before we get started, we need to confirm your email address to ensure that we have the correct information.</strong><br></br><br></br><br></br>

<strong>Please follow these steps to complete your registration:</strong><br></br><br></br>

<strong>Would you like to receive future text messages about Beyfortus updates?</strong>

<strong>Sanofi is here to help support your patients, their families, and caregivers.</strong><br></br><br></br>For more information regarding Beyfortus<sup>®</sup> (nirsevimab-alip) Injection, call <a.callPhoneNumberBeyfortus>1-855-BEYFORTUS (1-855-239-3678)</a.callPhoneNumberBeyfortus> or sign up below to receive the latest updates via email.<br></br><br></br><strong>All fields are required.</strong>

Would you like to learn more about Beyfortus<sup>®</sup> (nirsevimab-alip) 50 mg and 100 mg injection?<br></br>Leave us your contact details, and a Sanofi representative will be in touch.<br></br><br></br><strong>All fields are required.</strong>

<strong>Would you also like to receive future messages and updates about Beyfortus?</strong>

Do you want to participate in the Beyfortus Reservation Program?

What information are you interested in learning more about? (Optional)

Are you enrolled in CENRIFKI REMS?

Request a visit from your local ALPROLIX representative to learn more.<br></br><br></br>Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>.<br></br><br></br><strong>All fields are required.</strong>

Request a visit from your local ALTUVIIIO representative to learn more.<br></br><br></br>Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>.<br></br><br></br><strong>All fields are required.</strong>

Request a visit from your local QFITLIA representative to learn more.<br></br><br></br>Call <a.callPhoneNumberAltuviiio>1-800-745-4447</a.callPhoneNumberAltuviiio>, Option 5, or complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>.<br></br><br></br><strong>All fields are required.</strong>

Sign up to schedule an office visit with your ALPROLIX® Representative or receive updates about ALPROLIX.<br></br><br></br>Please complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>.<br></br><br></br><strong>All fields are required.</strong>

Sign up to schedule an office visit with your local Sanofi representative and/or to receive updates about Qfitlia.<br></br><br></br>Please complete the form below. The information you provide will be maintained in accordance with our <a.usPrivacyPolicy>Privacy Policy</a.usPrivacyPolicy>.<br></br><br></br><strong>All fields are required (unless otherwise specified).</strong>

All fields are required. (unless otherwise specified)

Sanofi biedt u exclusieve content over onze verschillende therapeutische gebieden op één portal speciaal voor professionals in de gezondheidszorg, inclusief wetenschappelijk nieuws, een lijst met evenementen en tools en diensten voor uw dagelijkse praktijk.

Bevestig uw status

Welcome to ITP Sanofi Campus

De inhoud van deze website is alleen toegankelijk voor geregistreerde gebruikers.

Log in alstublieft

Email verificatie

U ziet een voorbeeld van de portal. Wis uw cookies (bijvoorbeeld door uw browservenster te sluiten) om terug te gaan naar de openbare modus.

We hebben onze privacyverklaring bijgewerkt om je gegevens beter te beschermen en je ervaring te verbeteren. Neem even de tijd om de wijzigingen door te nemen door <privacyNewTab>hier te klikken</privacyNewTab>. Uw privacy is belangrijk voor ons. <br></br>Klik op doorgaan om te bevestigen dat u de nieuwe privacyverklaring hebt gelezen.

Update van de privacyverklaring

Communicatie toestemming

My consents

Password

Confirm password

{resultsCount, plural, one {resultaat} other {resultaten}}

Log in om toegang te krijgen tot de resultaten

U moet inloggen op uw account om toegang te krijgen tot medische inhoud.

Inloggen

Registreer in minder dan 1 minuut om toegang te krijgen tot de resultaten

U verlaat nu het Sanofi inhoudsgedeelte van onze site en komt in het inhoudsgedeelte voor extern medisch bibliografisch zoeken.

U verlaat nu het externe medische bibliografische zoekgedeelte van onze site en komt in het inhoudsgedeelte van Sanofi.

You are about to leave the T1D website

Welcome to the T1D Sanofi Website

Geniet van meer exclusieve inhouddoor door u vandaag te registreren

Welkom bij Campus Sanofi Nederland

Wetenschappelijk nieuws

Nieuwe inzichten in EoE en voedselherintroductie met dupilumab

Airway remodeling in asthma: Why targeting IL-4 and IL-13 matters

Beyfortus®▼(nirsevimab): effectiveness and public health impact in the real world