Artikel
Bron: Campus Sanofi
25 jun 2026

Chronic Rhinosinusitis with Nasal Polyps: The Interplay of Type 2 Inflammation and Smell Loss

Auteur: Sanofi

Editorial Team

Loss of the sense of smell is a major symptom of chronic rhinosinusitis with nasal polyps, affecting up to 90% of patients.^1,2 Smell loss, which results in considerable lifestyle and psychological disease burden³, is a key indicator of type 2 inflammation⁴ and may be the first sign of the disease recurrence.^1,2

Type 2 Inflammation and Loss of Smell

Loss of the sense of smell is one of the major symptoms of CRSwNP^1,2
It impacts patients QoL³, and may persist even after the surgery⁴
Type 2 inflammation may play a role in yielding anosmia/hyposmia⁵
It affects ≈90% of CRSwNP patients¹
Anosmia/hyposmia can be an early indicator of disease recurrence^1,2
Degree of type 2 inflammation is correlated with severity of impairment of smell^1,2

Smell loss is associated with type 2 inflammation^5–9

Smell loss represents a major burden for CRSwNP patients^1,2

Reduced quality of life (HR-QoL)^1,10

Daily activities are affected³

Depression, anxiety, phobia, irritation, fatigue etc.³

Altered interpersonal relationships¹¹

Economic burden, decreased productivity¹²

Smell improvement as measure of disease control

1 - International Guidelines

Emphasize the importance of the loss of the ability to smell as a treatment target^13-14

2 - Assessment of olfaction

Is crucial for clinical evaluation of CRS¹

3 - Management of smell loss

Is complex and requires a multifaceted approach^19-21

1/3

1 - International Guidelines

Emphasize the importance of the loss of the ability to smell as a treatment target^13-14

2 - Assessment of olfaction

Is crucial for clinical evaluation of CRS¹

3 - Management of smell loss

Is complex and requires a multifaceted approach^19-21

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MAT-BE-2600575 (v1.0) 04/05/2026

Chronic Rhinosinusitis with Nasal Polyps: The Interplay of Type 2 Inflammation and Smell Loss

Type 2 Inflammation and Loss of Smell

Smell loss is associated with type 2 inflammation^5–9

Smell loss represents a major burden for CRSwNP patients^1,2

Smell improvement as measure of disease control

1 - International Guidelines

2 - Assessment of olfaction

3 - Management of smell loss

1 - International Guidelines

2 - Assessment of olfaction

3 - Management of smell loss

Abbreviations

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Gerelateerd

Type 2 Inflammation and Loss of Smell

Smell loss is associated with type 2 inflammation5–9

Smell loss represents a major burden for CRSwNP patients1,2

Smell improvement as measure of disease control

1 - International Guidelines

2 - Assessment of olfaction

3 - Management of smell loss

1 - International Guidelines

2 - Assessment of olfaction

3 - Management of smell loss

Abbreviations

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Gerelateerd

Smell loss is associated with type 2 inflammation^5–9

Smell loss represents a major burden for CRSwNP patients^1,2