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PULMO institute

What does it really take to move the needle in severe asthma care?

In this expert video series, Professor Brian Lipworth explores the evolving science of severe asthma – from the true predictive power of FeNO and eosinophils together, to spotting mucus plugging on CT, to why small airways disease may hide the largest share of type 2 inflammation in the lung. He also unpacks how comorbidities like nasal polyps, atopic dermatitis, and eosinophilic esophagitis can point toward a stronger response to biologics.

Professor Lipworth and Professor Klaus Rabe

Professor Lipworth is also joined by Professor Klaus Rabe for a candid cross-disease discussion on whether blood eosinophils tell the same story in asthma and COPD. These conversations are frank, thought-provoking, and clinically relevant. Whether you're managing patients in primary care or a specialist setting, this series will challenge how you think about severe asthma and the tools available to treat it.


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Severe Asthma Interviews with Prof. Brian Lipworth

Prof. Brian Lipworth

The predictive value of FeNO

Professor Brian Lipworth explains why FeNO is one of the most important markers of type 2 inflammation, and how to increase its predictive value even further.


Prof. Brian Lipworth

Recognizing Mucus Plugging in Severe Asthma

In this interview, Professor Brian Lipworth discusses why high-resolution CT plays an important role in severe asthma assessment, and explains how mucus plugging is linked to impaired lung function, small airways disease, and biologic treatment decisions.


Prof. Brian Lipworth

Why Type 2 Comorbidities Matter

Asthma doesn't stop at the lungs. Nasal polyps, atopic dermatitis, eosinophilic esophagitis - Type 2 inflammation is a whole body phenomenon. Professor Brian Lipworth explains why recognizing comorbidities helps build a more complete picture of the patient's disease.


Prof. Brian Lipworth

Understanding Small Airways Disease

“You're only treating the beach towel — not the tennis court”. Professor Brian Lipworth uses a brilliantly simple analogy to explain why small airways matter so much in severe asthma.


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COPD and Asthma: Are Eosinophils Different?

Prof. Klaus Rabe and prof. Brian Lipworth

COPD and Asthma: Are Eosinophils Different?

Blood eosinophils are a hot topic in both asthma and COPD. In this candid exchange, Professor Rabe and Professor Lipworth debate whether blood eosinophils are a true disease driver or simply a biomarker, why the 300 cells/µL threshold matters, and what the clinical trial data is really telling us.

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MAT-BE-2600936 v.1.0 08/2026