Discover the real-life impact of autoimmune Type 1 Diabetes (T1D) through the perspective of Sigurd’s parents. In this testimonial, they share their experiences of missed early signs, the sudden shock of diagnosis, and the profound impact that T1D has had on their family life.
In this testimonial film, Sigurd’s parents reflect on how they overlooked signs of Sigurd developing autoimmune T1D, the moment of realization, the shock of diagnosis, how their lives changed overnight, and what earlier detection could have meant:
<ul>
 <li>Sigurd’s mother speaks candidly about the toll of constant glucose monitoring device alarms and the emotional strain on their other children.</li>
 <li>Sigurd’s father shares how his lived experience with autoimmune T1D helped them adapt to Sigurd’s diagnosis. He also shares his opinions about whether he would have wanted to know in advance that Sigurd was developing autoimmune T1D.</li>
</ul>

Sigurd’s parent's message to healthcare professionals is clear: early detection through autoantibody screening has many benefits. It offers time to prepare, it can support families psychologically, and it can lessen the shock of diagnosis, for everyone whose daily life may be affected by autoimmune T1D.

<h3 style="text-align:center;">Part 1: How parents perceive the risk of their child developing autoimmune Type 1 Diabetes</h3>

Parent's experiences of stage 3 diagnosis of T1D.

TYPE-1-DIABETES

DIABETES

When a Child Gets Autoimmune Type 1 Diabetes

<h3 style="text-align:center;">Part 2: What it is like to discover that your child has autoimmune Type 1 Diabetes</h3>

<h3 style="text-align:center;">Part 3: What it takes to cope with the shock of diagnosis and to adjust to life with autoimmune T1D</h3>

<h3 style="text-align:center;">Part 4: Whether there is value in knowing early on if a family member is developing autoimmune Type 1 Diabetes</h3>

<h3 style="text-align:center;">Part 5: Everyday life with autoimmune type 1 diabetes</h3>

<h3 style="text-align:center;">Full video: When A Child Gets Autoimmune Type 1 Diabetes</h3>

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Parent's experiences of stage 3 diagnosis of T1D.

<h2>How does uncontrolled atopic dermatitis (AD) impact patients beyond the physical symptoms?</h2>
<h3>In addition to looking at clinical measures, it’s important to consider other ways AD may be impacting patients. Skin lesions and itch are just the tip of the iceberg.</h3>

86% of patients with uncontrolled moderateto- severe AD report suffering from daily itch1

Patients with moderate-to-severe AD report spending 31%-53% of the year in flare2

What burdens due to AD do your patients experience in their daily lives?

Understanding the broader consequences of uncontrolled AD and the complexity of its burden on patients’ lives is essential for comprehensive disease management.1

The itch that is common in AD can have a serious impact on both the quality and quantity of sleep a patient gets. Because of this, the time patients spend sleeping is an important sign of how AD is affecting them.3,4

In a survey that included over 2000 patients with AD,&nbsp;reported moderate-to-severe sleep disruption due to AD-related itch during the previous week3

Another study found that&nbsp;67 nights of sleep, or over 2 months per year,&nbsp;can be negatively impacted by AD in adults.2

<h3>This lack of sleep can have a negative impact leading to limitations on many aspects of life, from socializing to working. Sleep disruption can often also affect partners and caregivers.2,4</h3>

The itch that is so common in AD can have a cascading effect on patients’ lives, leading to sleep disturbances that in turn impact everyday functioning, including adverse effects on participation in activities and social interactions.2-4
The burden of AD is multifaceted, impacting the skin and so much more. To improve the quality of life of patients, interventions aimed at addressing the pathophysiology of AD are vital.

Beneath the skin of patients with AD—type 2 inflammation and the cytokines involved.

Referenties

Understanding the full scope of AD—the unseen burden on patients.

Sleep and QOL: the full impact on patients coping with the burden of AD

ATOPIC-DERMATITIS

DERMATOLOGY

Aïcha, a 53-year-old mother of three teenagers, was diagnosed with autoimmune T1D in her late 40s. The condition was not unfamiliar to her, as her sister had been diagnosed with it many years earlier at age 12. Aïcha's journey with autoimmune T1D continued with her twin boys also having the condition, while her daughter, thankfully, screened negative, offering some much-needed relief.

It’s important to recognise that people, like Aïcha, who have a first-degree relative with autoimmune T1D, have&nbsp;up to 15x higher risk of developing the condition&nbsp;compared to the general population.4&nbsp;Proactively screening for autoimmune T1D in those with a known family history of the condition allows you to detect it&nbsp;before&nbsp;symptoms arise.*5–7

A licensed clinical psychologist and part of the diabetes care team at Stanford University, Korey lives with autoimmune T1D, alongside coeliac disease and an autoimmune thyroid condition. His diagnoses have resulted in dietary restrictions that can make social gatherings tricky. Familiar with the lifestyle adaptations needed for life with autoimmune T1D, Korey is a keen advocate for screening and has already had his eldest tested for the condition.

People like Korey demonstrate the high degree of co-occurrence between autoimmune T1D and other autoimmune conditions. Of those living with autoimmune T1D,&nbsp;up to 9% also have coeliac disease, and up to 30% also have autoimmune thyroid conditions.8,9&nbsp;Understanding the genetic link between certain autoimmune conditions can help you identify which patients to screen as a priority.

<h2>Meet Alizée</h2>
Meet Alizée, a 30-year-old woman living with autoimmune T1D. With no family history of the condition and no other risk factors, her diagnosis at 19 years old came unexpectedly.

Although people with a family history of autoimmune T1D are at a significantly higher risk of developing the condition,&nbsp;the majority (~90%) of new diagnoses occur in people like Alizée, who have no family history of the condition.†4,10&nbsp;So, while some risk factors may position some individuals as higher priority screening candidates, it’s important to understand that everyone has the opportunity to get ahead of autoimmune T1D through universal screening.

Veerle is 34 years old and was diagnosed with autoimmune T1D after an initial misdiagnosis of type 2 diabetes. She was the first in her family to be diagnosed with autoimmune T1D but has distant cousins who have since been diagnosed too.

In a retrospective US study,&nbsp;~40% of adults with autoimmune T1D were initially misdiagnosed with another condition, with 77% of these cases being misdiagnosed as type 2 diabetes.‡11&nbsp;Misdiagnosis can delay proper insulin replacement therapy, resulting in prolonged hyperglycaemia and increasing the risk of diabetic ketoacidosis (DKA).11&nbsp;This underpins the importance of considering autoimmune T1D in certain individuals suspected as presenting with type 2 diabetes.

Healthcare professionals like you, who understand the importance of proactive screening, can transform the lives of those with autoimmune T1D. By detecting the condition before symptoms appear, you can help protect more people from the potential dangers of a later diagnosis.5–7,12,13

<h3>With timely diagnosis, it is estimated that an additional ~670,000 lives&nbsp;could be saved by 2040.14,15</h3>

While people from all backgrounds can develop autoimmune T1D, regardless of age or family history,&nbsp;10,16&nbsp;being vigilant about the risk factors can help you identify which patients should be prioritised for screening.1,8,9

<h3>GET 1 STEP AHEAD OF AUTOIMMUNE T1D THROUGH SCREENING.</h3>

Abbreviations, Footnotes &amp; References

The progression of autoimmune type 1 diabetes (T1D) is gradual, often detectable months or even years before symptoms arise.1–3 Through proactive screening, we can identify the condition well in advance.3 Meet our ambassadors living with autoimmune T1D and discover the risk factors to look out for when considering who to screen.

Real-life stories from people living with autoimmune T1D

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When a Child Gets Autoimmune Type 1 Diabetes

Sleep and QOL: the full impact on patients coping with the burden of AD

Real-life stories from people living with autoimmune T1D

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