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Dosing & Administration

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ADMINISTRATION

PRIMARY VACCINATION

  

  • Individuals 2 months old receive MenQuadfi as a 4-dose series at 2, 4, 6, and 12-18 months of age. The first dose may be given as early as 6 weeks1
  • Individuals 6 through 11 months old receive a 2-dose series, with the second dose administered in the second year of life and at least 3 months after the first dose1
  • Individuals 12 through 23 months old receive a 2-dose series, with the second dose administered at least 3 months after the first dose1
  • Individuals 2 years of age and older receive a single dose of MenQuadfi1

 

BOOSTER VACCINATION

 

  • A single dose of MenQuadfi may be administered to individuals 13 years of age and older who are at continued risk for meningococcal disease if at least 3 years have elapsed since a prior dose of meningococcal (groups A, C, W, Y) conjugate vaccine1

 

VACCINATION FOLLOWING PRIOR DOSE OF MENINGOCOCCAL POLYSACCHARIDE VACCINE

 

  • A single dose of MenQuadfi may be administered if at least 3 years have elapsed since a prior dose of meningococcal polysaccharide vaccine1
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PRESENTATION

  • MenQuadfi is supplied in 0.5-mL single-dose vials as a ready-to-use solution that does not require reconstitution1­
    • Does not contain any preservatives1
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According to the CDC, almost 40% of adolescents in the US may be at risk of contracting meningococcal disease because they have missed their 2nd dose of MenACWY.3

Consider MenQuadfi as an option for your adolescent patients.

PURCHASING INFORMATION

Based on its distinct formulation, MenQuadfi has a unique unique CPT® code (90619) for billing purposes.

  • MenQuadfi is available through direct purchasing channels and the Vaccines For Children (VFC) program to help keep both publicly and privately insured patients immunized
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Important Safety Information

MenQuadfi should not be administered to anyone who has had a severe allergic reaction to any component of the vaccine, or after a previous dose of MenQuadfi or any other tetanus toxoid-containing vaccine.

Appropriate medical treatment must be immediately available to manage potential anaphylactic reactions following administration of MenQuadfi.

Some individuals with altered immunocompetence, including some receiving immunosuppressant therapy, may have reduced immune responses to MenQuadfi. Persons with certain complement deficiencies and those receiving treatment that inhibits terminal complement activation (eg, eculizumab) are at increased risk for invasive disease caused by N meningitidis, including serogroups A, C, W, and Y, even if they develop antibodies following vaccination with MenQuadfi.

Syncope (fainting) may occur in association with administration of injectable vaccines, including MenQuadfi. Procedures should be in place to avoid injury from fainting.

Guillain-Barré syndrome (GBS) has been reported in temporal relationship following administration of another US-licensed meningococcal quadrivalent polysaccharide conjugate vaccine. The decision to give MenQuadfi to persons with a history of GBS should take into account the expected benefits and potential risks.

Immunization with MenQuadfi does not substitute for routine tetanus immunization.

Vaccination with MenQuadfi may not protect all vaccine recipients.

The most common adverse reactions following primary vaccination with MenQuadfi in infants 6 weeks through 23 months of age include tenderness, erythema, and swelling at the injection site; irritability, abnormal crying, drowsiness, appetite loss, fever, and vomiting. In individuals 2 years of age and older, the most common adverse reactions include pain at the injection site; myalgia, headache, and malaise. Other common adverse reactions in children 2 through 9 years of age include erythema and swelling at the injection site. In adolescents and adults, rates of solicited adverse reactions following a booster dose were comparable to those observed following primary vaccination. Other adverse reactions may occur.

Please see the full Prescribing Information for MenQuadfi.

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Important Safety Information

ACIP=Advisory Committee on Immunization Practices; CDC=Centers for Disease Control and Prevention; Men ACWY=N meningitidis serogroups A, C, W, and Y.

CPT (Current Procedural Terminology) is a registered trademark of the American Medical Association.

MenQuadfi is a registered trademark of Sanofi.

REFERENCES:
1. MenQuadfi [Prescribing Information]. Sanofi.
2. Mbaeyi SA, Bozio CH, Duffy J, et al. Meningococcal vaccination: recommendations of the Advisory Committee on Immunization Practices, United States, 2020. MMWR Recomm Rep. 2020;69(9):1-41.
3. Pingali C, Yankey D, Elam-Evans LD, et al. National vaccination coverage among adolescents aged 13-17 years—National Immunization Survey-Teen, United States, 2021. MMWR Morb Mortal Wkly Rep. 2022;71(35):1101-1108.

MAT-US-2007152-v12.0-11/2025

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