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Le risque d’exacerbation augmente après chaque exacerbation1

Basé sur les données d'une vaste cohorte de 73 106 patients canadiens hospitalisés (âge moyen 75 ans) pour la première fois en raison d'une exacerbation sévère de la BPCO (1990-2005, suivis jusqu'au décès ou jusqu'au 31 mars 2007).

*Les exacerbations sévères ont été définies comme celles ayant entraîné une hospitalisation suite à un diagnostic primaire de BPCO.

b Ajusté en fonction de l’age, du sexe et du score de la maladie.2

De nombreux patients peuvent être encore symptomatiques voire continuer de souffrir d’exacerbations, malgré un traitement optimisé.

Écoutez le professeur Nicola Hanania : « La prévention des exacerbations est l'objectif clé »

2:07 minutes


Nicola Hanania est professeur de médecine, chef de section des soins intensifs pulmonaires et de médecine du sommeil à l'hôpital Ben Taub de Houston, au Texas, et directeur du centre de recherche clinique sur les voies respiratoires, ACRC, au Bear College of Medicine.

Écoutez l'intégralité de l'épisode du podcast sur le site d'EMJ.

Sponsorisé par Sanofi et Regeneron, en partenariat avec EMJ. 

Les exacerbations de BPCO peuvent entraîner un déclin accéléré de la fonction pulmonaire3,e

  • La perte annuelle de fonction pulmonaire a presque doublé3
  • Un déclin irréversible de la fonction pulmonaire peut survenir après une seule exacerbation de BPCO3

c- Ou bithérapie inhalée si les CSI sont contre-indiqués.15
d- Essai de phase 3, randomisé, en double aveugle, de 52 semaines, évaluant l'efficacité et l'innocuité de la trithérapie furoate de fluticasone/uméclidinium/vilanterol par rapport au furoate de fluticasone/vilanterol ou à l'uméclidinium/vilanterol chez des patients âgés de ≥ 40 ans atteints de BPCO symptomatique et d'un antécédents d'exacerbations.2
e- VEMS diminue après une seule exacerbation modérée à sévère. Basé sur une analyse rétrospective des données de 586 patients atteints de BPCO modérée à sévère.5

HRA, rapport de risque ajusté ; BPCO, Bronchopneumopathie chronique obstructive ; VEMS, volume expiratoire forcé en 1 seconde ; QdV, qualité de vie

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