- Artículo
- Fuente: Campus Sanofi
- 10 feb 2023
1 min
Patofisiología del Asma Tipo 2
IL-4, IL-13 e IL-5 son factores clave en la inflamación tipo 2 en Asma.
IL-4 e IL-13 son citoquinas Tipo 2 con roles distintos y superpuestos 3
Adapted from Hammad H and Lambrecht BN, 2008,4 and Robinson D et al, 2017 3
Type 2 inflammation in asthma can result in increased exacerbations and decreased lung function 3
IL-4 and IL-13 increase expression of the high-affinity IgE receptor FcεRI, which results in increased IgE/anti-IgE mediated histamine reléase 7
Adapted from Froidure A et al, 2016,5 and Robinson D et al, 2017 3.
| IL4 y IL3 son citoquinas Tipo 2 con roles distintos y superpuestos 3 |
ILC2, type 2 innate lymphoid cells; TSLP, thymic stromal lymphopoietin.
Referencias
- Seys SF, Scheers H, Van den Brande P, et al. Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients. Respir Res. 2017;18(1):39. doi:10.1186/s12931-017-0524-y
- Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014;133(2):388-394.
- Robinson D, Humbert M, Buhl R, et al. Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161-175.
- Hammad H, Lambrecht BN. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat Rev Immunol. 2008;8(3):193-204.
- Froidure A, Mouthuy J, Durham SR, Chanez P, Sibille Y, Pilette C. Asthma phenotypes and IgE responses. Eur Respir J. 2016;47(1):304-319.
- Zissler UM, Esser-von Bieren J, Jakwerth CA, Chaker AM, Schmidt-Weber CB. Current and future biomarkers in allergic asthma. Allergy. 2016;71(4):475-494.
- Kaur D, Hollins F, Woodman L, et al. Mast cells express IL-13Rα1: IL-13 promotes human lung mast cell proliferation and FcεRI expression. Allergy. 2006;61(9):1047-1053.